Identification of peripheral inflammatory markers between normal control and Alzheimer's disease.
Identification of peripheral inflammatory markers between normal control and Alzheimer's disease.
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DOI：
10.1186/1471-2377-11-51
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发表时间：
2011-05-12
期刊：
影响因子：
2.6
通讯作者：
Kim YY
中科院分区：
文献类型：
--
作者：
Kim SM;Song J;Kim S;Han C;Park MH;Koh Y;Jo SA;Kim YY
多种致病因素可能参与阿尔茨海默病（AD）的病理生理。外周血标志物已被用于评估与AD和轻度认知障碍（MCI）相关的生化变化，并参与其病理生理。血浆样本和临床数据来自安山老年研究（AGE研究）的参与者。在正常对照组（NC）、MCI组和AD组中测量了四种候选生物标志物的血浆浓度：白细胞介素-8 （IL-8）、IL-10、单核细胞趋化蛋白-1 （MCP-1）和肿瘤坏死因子-α (TNF-α)。记录身体质量指数（BMI）、迷你精神状态检查（MMSE）、临床痴呆评分（CDR）评分和同型半胱氨酸水平，并记录社会和人口统计学信息。随机抽取59例受试者进行分析[NC (n = 21)， MCI（n = 20）和AD(n = 18)]。人口学数据中，教育年限与诊断状态相关（p < 0.0001）。MCI组和AD组的心血管疾病、BMI和非甾体抗炎药的使用与NC组相比均无显著差异。三组受试者的炎症性疾病或病情、白细胞计数、纤维蛋白原和同型半胱氨酸水平均无显著差异。MCI和AD患者血浆IL-8水平均低于正常对照组（p < 0.0001）。MCI和AD患者MCP-1、IL-10、TNF-α水平相似。我们的研究表明MCI和AD患者血浆IL-8水平与功能状态之间存在独立的负相关关系。
Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impairment (MCI) and involved in their pathophysiology. Plasma samples and clinical data were obtained from participants in the Ansan Geriatric Study (AGE study). Plasma concentrations of four candidate biomarkers were measured in the normal control (NC), MCI, and AD group: interleukin-8 (IL-8), IL-10, monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-α (TNF-α). Body mass index (BMI), MMSE (Mini Mental State Examination), CDR(Clinical Dementia Rating) score and homocystein level were recorded with social and demographic information. Total of 59 subjects were randomly selected for this analysis [NC (n = 21), MCI(n = 20) and AD(n = 18)]. In demographic data, educational year was correlated with the diagnosis states ( p < 0.0001). No significant differences in cardiovascular disease, BMI and use of NSAIDs were found in MCI or AD group compared with NC group, respectively. The involvement of inflammatory illness or conditions in subjects, WBC count, fibrinogen and homocystein of the three groups, but no significant differences were found in each groups. The plasma IL-8 level was lower in MCI and AD patients compared with the normal control group (respectively, p < 0.0001). The MCI and AD patients had similar MCP-1, IL-10, and TNF-α level. Our study suggests the existence of an independent and negative relationship between plasma IL-8 levels and functional status in MCI and AD patients.
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影响因子：
4.8
作者：
Richartz, E;Stransky, E;Schott, K
通讯作者：
Schott, K
影响因子：
10.6
作者：
Simen, BB;Duman, CH;Duman, RS
通讯作者：
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影响因子：
56.9
作者：
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通讯作者：
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DOI：
10.1093/gerona/54.7.m357
发表时间：
1999-07-01
影响因子：
5.1
作者：
Bruunsgaard, H;Andersen-Ranberg, K;Pedersen, BK
通讯作者：
Pedersen, BK
影响因子：
4.5
作者：
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通讯作者：
Park, Min Kyu