Rational Design of Materials Interface for Efficient Capture of Circulating Tumor Cells.
Rational Design of Materials Interface for Efficient Capture of Circulating Tumor Cells.
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DOI：
10.1002/advs.201500118
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发表时间：
2015-11
期刊：
影响因子：
15.1
通讯作者：
Chen, Xiaodong
中科院分区：
文献类型：
--
作者：
Li, Yong-Qiang;Chandran, Bevita K.;Lim, Chwee Teck;Chen, Xiaodong
循环肿瘤细胞起源于原发肿瘤并深入血液循环，在了解肿瘤转移生物学过程中起着至关重要的作用，在肿瘤的早期诊断、预后判断和个体化治疗方面具有巨大的潜力。通过利用CTCs独特的生物物理和生化特性，人们开发了各种材料界面来捕获和检测血液中的CTCs。然而，由于外周血中CTC的数量极低，因此需要提高CTC捕获和检测的效率和特异性。在这方面，必须认真审查关于高效和选择性捕获四氯化碳的先进平台的众多报告，这些报告受到纳米技术和微细制造的最新进展的推动。本文综述了四氯化碳独特的生物物理和生化性质，总结了最近为改进四氯化碳捕获和检测而开发的关键材料界面，重点介绍了微流体、纳米结构底物和基于核磁共振的小型化系统的使用。还讨论了临床应用中捕获和检测CTCs的材料接口设计方面的挑战和未来的前景。
Originating from primary tumors and penetrating into blood circulation, circulating tumor cells (CTCs) play a vital role in understanding the biology of metastasis and have great potential for early cancer diagnosis, prognosis and personalized therapy. By exploiting the specific biophysical and biochemical properties of CTCs, various material interfaces have been developed for the capture and detection of CTCs from blood. However, due to the extremely low number of CTCs in peripheral blood, there exists a need to improve the efficiency and specificity of the CTC capture and detection. In this regard, a critical review of the numerous reports of advanced platforms for highly efficient and selective capture of CTCs, which have been spurred by recent advances in nanotechnology and microfabrication, is essential. This review gives an overview of unique biophysical and biochemical properties of CTCs, followed by a summary of the key material interfaces recently developed for improved CTC capture and detection, with focus on the use of microfluidics, nanostructured substrates, and miniaturized nuclear magnetic resonance‐based systems. Challenges and future perspectives in the design of material interfaces for capture and detection of CTCs in clinical applications are also discussed.
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DOI：
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发表时间：
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期刊：
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影响因子：
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