Human Albumin Fragments Nanoparticles as PTX Carrier for Improved Anti-cancer Efficacy.
Human Albumin Fragments Nanoparticles as PTX Carrier for Improved Anti-cancer Efficacy.
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人白蛋白片段纳米颗粒作为 PTX 载体提高抗癌功效
DOI：
10.3389/fphar.2018.00582
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发表时间：
2018
影响因子：
5.6
通讯作者：
Hai Q
中科院分区：
文献类型：
--
作者：
Ge L;You X;Huang J;Chen Y;Chen L;Zhu Y;Zhang Y;Liu X;Wu J;Hai Q
为了提高紫杉醇的抗癌活性，本文将人血清白蛋白片段（HSAFs）纳米粒（NPs）作为紫杉醇（PTX）的载体。人白蛋白通过降解破碎成片段并通过京尼平交联以形成HSAF纳米颗粒，以获得更好的生物相容性、改善的PTX药物负载和持续的药物释放。与交联的人血清白蛋白纳米粒相比，HSAF-NPs显示出相对较小的粒径、较高的载药量和改善的缓释。细胞和动物结果均表明，PTX包封的HSAF-NP显示出良好的抗癌性能。抗癌实验结果证实了具有快速细胞内化的纳米粒具有更好的抑瘤作用。这些发现不仅为癌症治疗提供了一个安全可靠的药物递送纳米粒平台，而且为基于白蛋白的纳米粒的优化设计提供了基础信息。
For enhanced anti-cancer performance, human serum albumin fragments (HSAFs) nanoparticles (NPs) were developed as paclitaxel (PTX) carrier in this paper. Human albumins were broken into fragments via degradation and crosslinked by genipin to form HSAF NPs for better biocompatibility, improved PTX drug loading and sustained drug release. Compared with crosslinked human serum albumin NPs, the HSAF-NPs showed relative smaller particle size, higher drug loading, and improved sustained release. Cellular and animal results both indicated that the PTX encapsulated HSAF-NPs have shown good anti-cancer performance. And the anticancer results confirmed that NPs with fast cellular internalization showed better tumor inhibition. These findings will not only provide a safe and robust drug delivery NP platform for cancer therapy, but also offer fundamental information for the optimal design of albumin based NPs.
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影响因子：
14
作者：
Li, WenTing;Peng, JinRong;Qian, ZhiYong
通讯作者：
Qian, ZhiYong
影响因子：
5.8
作者：
Jiang, Liqun;Xu, Yisheng;Liu, Jianping
通讯作者：
Liu, Jianping
影响因子：
10.8
作者：
Morral-Ruiz, G.;Melgar-Lesmes, P.;Garcia-Celma, M. J.
通讯作者：
Garcia-Celma, M. J.
DOI：
10.1016/j.jconrel.2010.02.027
发表时间：
2010-06-15
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Li Y;Xiao K;Luo J;Lee J;Pan S;Lam KS
通讯作者：
Lam KS
影响因子：
5.8
作者：
Li, Chunlei;Li, Yanhui;Cui, Jingxia
通讯作者：
Cui, Jingxia