Placental implications of peroxisome proliferator-activated receptors in gestation and parturition.

Placental implications of peroxisome proliferator-activated receptors in gestation and parturition.
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DOI:
10.1155/2008/758562
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发表时间:
2008
期刊:
影响因子:
2.9
通讯作者:
Blanchon L
Blanchon L
中科院分区:
医学3区
文献类型:
--
作者:
Borel V;Gallot D;Marceau G;Sapin V;Blanchon L

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胎盘是哺乳动物妊娠期间胚胎和胎儿正常发育所必需的过渡性结构。与核受体家族的其他成员一样,过氧化物酶体增殖物激活受体(PPARs)已知参与胎盘形成期间发生的生理和病理事件。 这种胎盘受累最近已被审查,重点是胎盘发育的早期阶段(植入和侵入等),小鼠PPARs敲除表型和细胞滋养层生理学。在这篇综述中,我们描述了胎盘参与的PPARs(例如,脂肪运输和代谢等)在妊娠晚期和羊膜中,突出了它们在炎症过程中的作用(例如,绒毛膜炎),代谢紊乱(例如,糖尿病)和分娩。
The placenta is a transitory structure indispensable for the proper development of the embryo and fetus during mammalian gestation. Like other members of the nuclear receptor family, the peroxisome proliferator-activated receptors (PPARs) are known to be involved in the physiological and pathological events occurring during the placentation. This placental involvement has been recently reviewed focusing on the early stages of placental development (implantation and invasion, etc.), mouse PPARs knockout phenotypes, and cytotrophoblast physiology. In this review, we describe the placental involvement of PPARs (e.g., fat transport and metabolism, etc.) during the late stages of gestation and in the amniotic membranes, highlighting their roles in the inflammation process (e.g., chorioamnionitis), metabolic disorders (e.g., diabetes), and parturition.
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