Early childhood obesity is associated with compromised cerebellar development.
Early childhood obesity is associated with compromised cerebellar development.
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DOI：
10.1080/87565640802530961
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发表时间：
2009
影响因子：
1.5
通讯作者：
Leonard CM
中科院分区：
文献类型：
--
作者：
Miller JL;Couch J;Schwenk K;Long M;Towler S;Theriaque DW;He G;Liu Y;Driscoll DJ;Leonard CM
As part of a study investigating commonalities between Prader-Willi syndrome (PWS — a genetic imprinting disorder) and early-onset obesity of unknown etiology (EMO) we measured total cerebral and cerebellar volume on volumetric MRI images. Individuals with PWS (n=16) and EMO (n=12) had smaller cerebellar volumes than a control group of 15 siblings (p=0.02 control vs. EMO; p=0.0005 control vs. PWS), although there was no difference among the groups in cerebral volume. Individuals with PWS and EMO also had impaired cognitive function: general intellectual ability (GIA): PWS 65 ± 25; EMO 81 ± 19; and Controls 112 ± 13 (p<0.0001 controls vs. PWS and controls vs. EMO). As both conditions are characterized by early-onset obesity and slowed cognitive development, these results raise the possibility that early childhood obesity retards both cerebellar and cognitive development.
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