SARS-CoV-2 coinfection with additional respiratory virus does not predict severe disease: a retrospective cohort study.
SARS-CoV-2 coinfection with additional respiratory virus does not predict severe disease: a retrospective cohort study.
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DOI：
10.1093/jac/dkab244
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发表时间：
2021-09-23
期刊：
影响因子：
--
通讯作者：
Baron SW
中科院分区：
文献类型：
--
作者：
Chekuri S;Szymczak WA;Goldstein DY;Nori P;Marrero Rolon R;Spund B;Singh-Tan S;Mohrmann L;Assa A;Southern WN;Baron SW
截至二零二一年七月，由严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）大流行夺去了超过400万人的生命，并继续对公共卫生构成严重威胁。我们的回顾性研究利用SARS-CoV-2患者的呼吸道病原体组（RPP）结果来确定合并感染（即SARS-CoV-2阳性与其他呼吸道病毒）是否与更严重的表现和结局相关。所有流感/呼吸道合胞病毒检测阴性的患者，在纽约的一个大型学术医疗中心，在SARS-CoV-2检测阳性的7天内接受了RPP检测。将RPP阴性的SARS-CoV-2阳性患者与SARS-CoV-2阳性且RPP病毒阳性的患者在生物标志物、需氧量和严重COVID-19结局（定义为机械通气或30天内死亡）方面进行比较。在306例SARS-CoV-2阳性患者中，14例（4.6%）非流感病毒（合并感染）呈阳性。与合并感染组相比，SARS-CoV-2阳性且RPP阴性的患者具有更高的炎症标志物，并且更容易入院（P = 0.01）。 仅SARS-CoV-2组有111例（36.3%）患者发生严重COVID-19结局，合并感染组有3例（21.4%）患者发生严重COVID-19结局（P = 0.24）。 与仅感染SARS-CoV-2的患者相比，沿着非流感呼吸道病毒感染的SARS-CoV-2患者在就诊时病情较轻，更容易入院，但没有更严重的结局。
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) claimed over 4 million lives by July 2021 and continues to pose a serious public health threat. Our retrospective study utilized respiratory pathogen panel (RPP) results in patients with SARS-CoV-2 to determine if coinfection (i.e. SARS-CoV-2 positivity with an additional respiratory virus) was associated with more severe presentation and outcomes. All patients with negative influenza/respiratory syncytial virus testing who underwent RPP testing within 7 days of a positive SARS-CoV-2 test at a large, academic medical centre in New York were examined. Patients positive for SARS-CoV-2 with a negative RPP were compared with patients positive for SARS-CoV-2 and positive for a virus by RPP in terms of biomarkers, oxygen requirements and severe COVID-19 outcome, as defined by mechanical ventilation or death within 30 days. Of the 306 SARS-CoV-2-positive patients with RPP testing, 14 (4.6%) were positive for a non-influenza virus (coinfected). Compared with the coinfected group, patients positive for SARS-CoV-2 with a negative RPP had higher inflammatory markers and were significantly more likely to be admitted (P = 0.01). Severe COVID-19 outcome occurred in 111 (36.3%) patients in the SARS-CoV-2-only group and 3 (21.4%) patients in the coinfected group (P = 0.24). Patients infected with SARS-CoV-2 along with a non-influenza respiratory virus had less severe disease on presentation and were more likely to be admitted—but did not have more severe outcomes—than those infected with SARS-CoV-2 alone.
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DOI：
10.1016/j.jcv.2009.03.008
发表时间：
2009-05
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Greer RM;McErlean P;Arden KE;Faux CE;Nitsche A;Lambert SB;Nissen MD;Sloots TP;Mackay IM
通讯作者：
Mackay IM
DOI：
10.1164/rccm.202002-0445oc
发表时间：
2020-06-01
影响因子：
24.7
作者：
Feng, Yun;Ling, Yun;Qu, Jieming
通讯作者：
Qu, Jieming
影响因子：
6.4
作者：
Leuzinger, Karoline;Roloff, Tim;Hirsch, Hans H.
通讯作者：
Hirsch, Hans H.
影响因子：
12.7
作者：
Ding, Qiang;Lu, Panpan;Liu, Mei
通讯作者：
Liu, Mei
影响因子：
4.4
作者：
Blyth CC;Webb SA;Kok J;Dwyer DE;van Hal SJ;Foo H;Ginn AN;Kesson AM;Seppelt I;Iredell JR;ANZIC Influenza Investigators;COSI Microbiological Investigators
通讯作者：
COSI Microbiological Investigators