Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?
Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?
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DOI：
10.1016/j.jcv.2009.03.008
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Mackay IM
中科院分区：
文献类型：
--
作者：
Greer RM;McErlean P;Arden KE;Faux CE;Nitsche A;Lambert SB;Nissen MD;Sloots TP;Mackay IM
由于全年发生的 HRV 感染总数很高，因此人类鼻病毒 (HRV) 经常与呼吸道中发现的其他病毒同时检测到。这一功能此前已将 HRV 归为急性呼吸道感染的乘客。尽管 HRV 具有致病潜力、与感染相关的医疗支出以及相对不受控制的抗病毒状态诱导，但 HRV 的特征仍然很差，并且很少被纳入诊断组中。检验呼吸道病毒同时出现的可能性或多或少的假设，特别是 HRV。对 17 种病毒（包括 HRV 毒株）的 1247 份样本进行基于 PCR 的回顾性分析，鉴定出 131 份样本含有两个或更多目标。我们调查了联合检测的比例，并比较了 HRV 阳性组中上呼吸道和下呼吸道表现的比例。进行单变量列联表和多变量逻辑回归分析，以确定联合检测中存在的病毒之间的关联趋势。许多共同检测都是以一定的模式发生的。特别是，HRV 检测与检测人类腺病毒、冠状病毒、博卡病毒、偏肺病毒、呼吸道合胞病毒、副流感病毒、甲型流感病毒以及多瘤病毒 KIPyV 和 WUPyV 的概率降低相关（p ≤ 0.05）。没有单一的 HRV 物种或特定菌株群占主导地位。 HRV 在病毒联合检测中代表性不足。在一段时间内，HRV 可能会降低宿主被其他病毒感染的可能性。
Human rhinoviruses (HRVs) are often concurrently detected with other viruses found in the respiratory tract because of the high total number of HRV infections occurring throughout the year. This feature has previously relegated HRVs to being considered passengers in acute respiratory infections. HRVs remain poorly characterized and are seldom included as a target in diagnostic panels despite their pathogenic potential, infection-associated healthcare expenditure and relatively unmoderated elicitation of an antiviral state. To test the hypothesis that respiratory viruses are proportionately more or less likely to co-occur, particularly the HRVs. Retrospective PCR-based analyses of 1247 specimens for 17 viruses, including HRV strains, identified 131 specimens containing two or more targets. We investigated the proportions of co-detections and compared the proportion of upper vs. lower respiratory tract presentations in the HRV positive group. Both univariate contingency table and multivariate logistic regression analyses were conducted to identify trends of association among the viruses present in co-detections. Many of the co-detections occurred in patterns. In particular, HRV detection was associated with a reduced probability of detecting human adenoviruses, coronaviruses, bocavirus, metapneumovirus, respiratory syncytial virus, parainfluenza virus, influenza A virus, and the polyomaviruses KIPyV and WUPyV (p ≤ 0.05). No single HRV species nor cluster of particular strains predominated. HRVs were proportionately under-represented among viral co-detections. For some period, HRVs may render the host less likely to be infected by other viruses.
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影响因子：
9.4
作者：
Brunstein, John D.;Cline, Christy L.;Thomas, Eva
通讯作者：
Thomas, Eva
影响因子：
5.1
作者：
GLEZEN, WP;LODA, FA;DENNY, FW
通讯作者：
DENNY, FW
影响因子：
9.4
作者：
Arola, A;Santti, J;Hyypia, T
通讯作者：
Hyypia, T
DOI：
10.1165/rcmb.2004-0417oc
发表时间：
2006-02-01
影响因子：
6.4
作者：
Chen, Y;Hamati, E;Wu, R
通讯作者：
Wu, R
DOI：
10.1164/rccm.200306-737oc
发表时间：
2003-11-01
影响因子：
24.7
作者：
Brooks, GD;Buchta, KA;Busse, WW
通讯作者：
Busse, WW