Neuronal expression of the ubiquitin E3 ligase APC/C-Cdh1 during development is required for long-term potentiation, behavioral flexibility, and extinction.
Neuronal expression of the ubiquitin E3 ligase APC/C-Cdh1 during development is required for long-term potentiation, behavioral flexibility, and extinction.
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DOI：
10.1016/j.nlm.2012.11.005
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发表时间：
2013-02
影响因子：
2.7
通讯作者：
Klann E
中科院分区：
文献类型：
--
作者：
Pick JE;Wang L;Mayfield JE;Klann E
Cdh1 是后期促进复合物/环体 (APC/C) 的调节亚基，APC/C 是一种已知参与调节细胞周期进程的泛素 E3 连接酶。最近的研究证明了 Cdh1 在神经元发育和成人突触可塑性以及记忆过程中的作用。为了更好地表征 Cdh1 在突触可塑性和记忆中的贡献，我们使用神经元特异性烯醇化酶 (Nse) 启动子生成了条件敲除小鼠，其中 Cdh1 从分化开始就在神经元中被消除。尽管我们检测到 Nse-Cdh1 敲除 (KO) 小鼠海马切片的长时程增强 (LTP) 受损，但一些海马依赖性记忆任务的表现仍然完好无损。然而，Nse-Cdh1 KO 小鼠表现出行为灵活性受损和先前巩固的记忆消失。这些发现表明 Cdh1 在调节巩固记忆的更新中发挥着作用。
Cdh1 is a regulatory subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), a ubiquitin E3 ligase known to be involved in regulating cell cycle progression. Recent studies have demonstrated a role for Cdh1 in neurons during developmental and adult synaptic plasticity, as well as memory. In order to better characterize the contribution of Cdh1 in synaptic plasticity and memory, we generated conditional knockout mice using a neuron-specific enolase (Nse) promoter where Cdh1 was eliminated in neurons from the onset of differentiation. Although we detected impaired long-term potentiation (LTP) in hippocampal slices from the Nse-Cdh1 knockout (KO) mice, performance on several hippocampus-dependent memory tasks remained intact. However, the Nse-Cdh1 KO mice exhibited impaired behavioral flexibility and extinction of previously consolidated memories. These findings suggest a role for Cdh1 in regulating the updating of consolidated memories.
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影响因子：
56.9
作者：
Konishi, Y;Stegm端ller, J;Bonni, A
通讯作者：
Bonni, A
影响因子：
2
作者：
Kuczera, Tanja;Stilling, Roman Manuel;Fischer, Andre
通讯作者：
Fischer, Andre
通过神经胶质调节突触连通性。
影响因子：
64.8
作者：
Eroglu, Cagla;Barres, Ben A.
通讯作者：
Barres, Ben A.
影响因子：
3.3
作者：
Kaplow, Margarita E.;Korayem, Adam H.;Venkatesh, Tadmiri R.
通讯作者：
Venkatesh, Tadmiri R.
DOI：
10.1073/pnas.96.20.11317
发表时间：
1999-09-28
影响因子：
11.1
作者：
Gieffers, C;Peters, BH;Peters, JM
通讯作者：
Peters, JM