Ghrelin-induced hypothermia: a physiological basis but no clinical risk.
Ghrelin-induced hypothermia: a physiological basis but no clinical risk.
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DOI：
10.1016/j.physbeh.2011.03.027
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发表时间：
2011-11-30
影响因子：
2.9
通讯作者：
Tong, Jenny
中科院分区：
文献类型：
--
作者：
Wiedmer, Petra;Strasser, Florian;Horvath, Tamas L.;Blum, David;DiMarchi, Richard;Lutz, Thomas;Schuermann, Annette;Joost, Hans-Georg;Tschoep, Matthias H.;Tong, Jenny
Ghrelin增加食物摄入量，减少能量消耗，促进积极的能量平衡。我们观察到一个严重的体温过低的情况下，在持续的生长激素释放肽治疗男性受试者，这表明生长激素释放肽可能在调节体温中发挥作用。因此，我们研究了在受控条件下，胃饥饿素治疗对啮齿动物和人类体温的影响。有趣的是，我们可以证明ghrelin结合在轴突末梢的内侧视前区的下丘脑位于附近的冷敏感神经元。生长激素释放肽受体的这种定位为生长激素释放肽调节体温提供了潜在的解剖学基础。然而，我们的后续研究也表明，无论是在大鼠中长期i.c.v.应用生长激素释放肽，还是单次s.c.在小鼠中冷暴露下注射导致身体核心温度的相关降低。此外，四小时的静脉注射ghrelin并没有降低健康人的体表温度。我们的结论是，虽然有一个理论的分子基础生长激素调节哺乳动物的体温，其幅度是无关的生理情况下。体温过低不太可能代表与该因子和途径相关的严重风险。
Ghrelin increases food intake and decreases energy expenditure, promoting a positive energy balance. We observed a single case of serious hypothermia during sustained ghrelin treatment in a male subject, suggesting that ghrelin may play a role in the regulation of body temperature. We therefore investigated the effect of ghrelin treatment on body temperature in rodents and humans under controlled conditions. Intriguingly, we could demonstrate ghrelin binding in axon terminals of the medial preoptic area of the hypothalamus located in the vicinity of cold-sensitive neurons. This localization of ghrelin receptors provides a potential anatomical basis for the regulation of body temperature by ghrelin. However, our follow-up studies also indicated that neither a chronic i.c.v. application of ghrelin in rats, nor a single s.c. injection under cold exposure in mice resulted in a relevant decrease in body core temperature. In addition, a four-hour intravenous ghrelin infusion did not decrease body surface temperature in healthy humans. We concluded that while there is a theoretical molecular basis for ghrelin to modify body temperature in mammals, its magnitude is irrelevant under physiologic circumstances. Hypothermia is not likely to represent a serious risk associated with this agent and pathway.
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影响因子：
--
作者：
BILLINGTON, CJ;BRIGGS, JE;LEVINE, AS
通讯作者：
LEVINE, AS
影响因子：
7.7
作者：
Tong J;Prigeon RL;Davis HW;Bidlingmaier M;Kahn SE;Cummings DE;Tschöp MH;D'Alessio D
通讯作者：
D'Alessio D
影响因子：
8.8
作者：
Strasser, F.;Lutz, T. A.;Maeder, M. T.;Thuerlimann, B.;Bueche, D.;Tschoep, M.;Kaufmann, K.;Holst, B.;Braendle, M.;von Moos, R.;Demmer, R.;Cerny, T.
通讯作者：
Cerny, T.
影响因子：
29
作者：
Wortley, KE;Anderson, KD;Sleeman, MW
通讯作者：
Sleeman, MW
影响因子：
16.2
作者：
Cowley, MA;Smith, RG;Horvath, TL
通讯作者：
Horvath, TL