Diversity of cholesterol exchange explained by dissolution into water
Diversity of cholesterol exchange explained by dissolution into water
复制标题
胆固醇交换的多样性通过溶解到水中来解释
作者：
E. Bojesen
通常认为脂质双层的稳定性是由于水对疏水性化合物溶解的弹性阻力1，2。然而，试图更详细地描述水的这种独特性质是困难的，一些作者4 -7认为非极性分子的分散吸引力（伦敦范德华力）是最重要的因素。非极性化合物向水中的转移动力学的细节可以阐明这一点。在这里，我描述的红细胞和脂蛋白之间的胆固醇交换的动力学分析，使它能够精确计算胆固醇溶解的两种结构的广泛不同的特定速率常数。分析还占定性的同源和异源分散系统在水中的不同交换动力学报告。
It is usually considered that the stability of lipid bilayers results from the elastic resistance of water to the dissolution of hydrophobic compounds1,2. However, attempts to describe this unique property of water in more detail2,3 have been difficult and some authors4–7 believe that the dispersion attraction of apolar molecules (London–van der Waals forces) is the most important factor. Details of the transfer kinetics into water of apolar compounds may elucidate this. Here I describe an analysis of the kinetics of cholesterol exchange between erythrocytes and lipoproteins that makes it possible to calculate precisely the widely differing specific rate constants of cholesterol dissolution from both kinds of structures. The analysis also accounts qualitatively for the different exchange kinetics reported for homologous and heterologous dispersed systems in water.
高密度脂蛋白中游离胆固醇分子的位置和运动。
DOI：
10.1016/0006-291x(81)90719-1
发表时间：
1981
影响因子：
3.1
作者：
Lund-Katz,S;Phillips,MC
通讯作者：
Phillips,MC