The role of TL1A and DR3 in autoimmune and inflammatory diseases.
The role of TL1A and DR3 in autoimmune and inflammatory diseases.
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DOI：
10.1155/2013/258164
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发表时间：
2013
影响因子：
4.6
通讯作者：
Nakamura M
中科院分区：
文献类型：
--
作者：
Aiba Y;Nakamura M
TNF样配体1A（TL 1A）结合其同源受体DR 3和诱饵受体DcR 3，是TNF超家族的鉴定成员。TL 1A对免疫细胞（包括辅助性T细胞和调节性T细胞）的细胞增殖、活化和分化发挥多效性作用。TL 1A及其两种受体在自身免疫性疾病如炎症性肠病（IBD）、类风湿性关节炎（RA）和强直性脊柱炎（AS）的血清和炎症组织中的表达增加。编码TL 1A的TNFSF 15基因的多态性与肠易激综合征、麻风和自身免疫性疾病（包括IBD、AS和原发性胆汁性肝硬化（PBC））的发病机制相关。在小鼠中，通过拮抗性抗体或DR 3基因缺失阻断TL 1A-DR 3相互作用可减轻多种自身免疫性疾病的严重程度，而T细胞或树突状细胞上持续的TL 1A表达可诱导IL-13依赖性小肠炎症。这表明TL 1A-DR 3相互作用的调节可能是几种自身免疫性疾病（包括IBD、RA、AS和PBC）的潜在治疗靶点。
TNF-like ligand 1A (TL1A), which binds its cognate receptor DR3 and the decoy receptor DcR3, is an identified member of the TNF superfamily. TL1A exerts pleiotropic effects on cell proliferation, activation, and differentiation of immune cells, including helper T cells and regulatory T cells. TL1A and its two receptors expression is increased in both serum and inflamed tissues in autoimmune diseases such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). Polymorphisms of the TNFSF15 gene that encodes TL1A are associated with the pathogenesis of irritable bowel syndrome, leprosy, and autoimmune diseases, including IBD, AS, and primary biliary cirrhosis (PBC). In mice, blocking of TL1A-DR3 interaction by either antagonistic antibodies or deletion of the DR3 gene attenuates the severity of multiple autoimmune diseases, whereas sustained TL1A expression on T cells or dendritic cells induces IL-13-dependent small intestinal inflammation. This suggests that modulation of TL1A-DR3 interaction may be a potential therapeutic target in several autoimmune diseases, including IBD, RA, AS, and PBC.
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影响因子：
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期刊：
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