Improved estimates of 222 nm far-UVC susceptibility for aerosolized human coronavirus via a validated high-fidelity coupled radiation-CFD code.
Improved estimates of 222 nm far-UVC susceptibility for aerosolized human coronavirus via a validated high-fidelity coupled radiation-CFD code.
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通过验证的高保真耦合辐射-CFD代码改进了对雾化人类冠状病毒222 nm远紫外线敏感性的估计。
DOI：
10.1038/s41598-021-99204-0
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发表时间：
2021-10-07
影响因子：
4.6
通讯作者：
Atkinson KD
中科院分区：
文献类型：
--
作者：
Buchan AG;Yang L;Welch D;Brenner DJ;Atkinson KD
通过气溶胶传播SARS-CoV-2在COVID-19在地球仪的快速传播中发挥了重要作用。通风不足的室内环境会造成严重的感染风险。虽然疫苗抑制了传播，但它们不是100%有效的，而且变种和新病毒的风险始终存在。因此，许多努力都集中在空气消毒的方法上。一种这样的方法涉及使用危害最小的222 nm远UVC光。虽然已经进行了少量的对照实验研究，但确定这种方法的功效是困难的，因为腔室或房间的几何形状以及其中的空气流动影响远紫外线照射和气雾剂停留时间。幸运的是，计算多物理场建模允许在这些复杂的情况下克服病毒灭活的剂量平均评估的不足。本文介绍了第一次验证的WYVERN辐射计算流体动力学代码远紫外线空气消毒对存活分数的测量，和第一个测量知情的建模方法，以估计远紫外线空气中的病毒易感性。除了证明代码的可靠性（高出约70%）外，我们的研究结果还表明，雾化的人类冠状病毒比以前认为的更容易受到远紫外线的影响。
Transmission of SARS-CoV-2 by aerosols has played a significant role in the rapid spread of COVID-19 across the globe. Indoor environments with inadequate ventilation pose a serious infection risk. Whilst vaccines suppress transmission, they are not 100% effective and the risk from variants and new viruses always remains. Consequently, many efforts have focused on ways to disinfect air. One such method involves use of minimally hazardous 222 nm far-UVC light. Whilst a small number of controlled experimental studies have been conducted, determining the efficacy of this approach is difficult because chamber or room geometry, and the air flow within them, influences both far-UVC illumination and aerosol dwell times. Fortunately, computational multiphysics modelling allows the inadequacy of dose-averaged assessment of viral inactivation to be overcome in these complex situations. This article presents the first validation of the WYVERN radiation-CFD code for far-UVC air-disinfection against survival fraction measurements, and the first measurement-informed modelling approach to estimating far-UVC susceptibility of viruses in air. As well as demonstrating the reliability of the code, at circa 70% higher, our findings indicate that aerosolized human coronaviruses are significantly more susceptible to far-UVC than previously thought.
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DOI：
10.1063/5.0050058
发表时间：
2021-05
期刊：
Physics of fluids (Woodbury, N.Y. : 1994)
影响因子：
--
作者：
He R;Liu W;Elson J;Vogt R;Maranville C;Hong J
通讯作者：
Hong J
DOI：
10.1016/s2468-2667(21)00012-8
发表时间：
2021-04
期刊：
The Lancet. Public health
影响因子：
--
作者：
Schwarzinger M;Watson V;Arwidson P;Alla F;Luchini S
通讯作者：
Luchini S
影响因子：
4.6
作者：
Buchan AG;Yang L;Atkinson KD
通讯作者：
Atkinson KD
HVAC系统对心脏重症监护病房中传染性气溶胶分散的影响。
DOI：
10.3390/ijerph17186582
发表时间：
2020-09-10
影响因子：
--
作者：
Anghel L;Popovici CG;Stătescu C;Sascău R;Verdeș M;Ciocan V;Șerban IL;Mărănducă MA;Hudișteanu SV;Țurcanu FE
通讯作者：
Țurcanu FE
DOI：
10.3390/ijerph17176052
发表时间：
2020-08-20
影响因子：
--
作者：
Chirico F;Sacco A;Bragazzi NL;Magnavita N
通讯作者：
Magnavita N