What pathogens have taught us about posttranslational modifications.
What pathogens have taught us about posttranslational modifications.
复制标题
哪些病原体教会了我们有关翻译后修饰的知识。
DOI：
10.1016/j.chom.2013.07.008
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发表时间：
2013-09-11
影响因子：
30.3
通讯作者：
Orth K
中科院分区：
文献类型：
--
作者：
Salomon D;Orth K
Pathogens use various mechanisms to manipulate host processes to promote infection. Decades of research on pathogens have revealed not only the molecular mechanisms that these microbes use to replicate and survive within host cells, but also seminal information on how host signaling machinery regulates cellular processes. Among these discoveries are mechanisms involving posttranslational modifications that alter the activity, localization, or interactions of the modified protein. Herein, we examine how pathogens have contributed to our basic understanding of three posttranslational modifications: phosphorylation, NMPylation, and ubiquitylation. Over the years, technologies, techniques and research tools have developed side by side with the study of pathogens, facilitating the discovery of protein modifications and furthering our understanding of how they contribute to both infection and cellular functions.
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影响因子：
6.8
作者：
Barford, D
通讯作者：
Barford, D
影响因子：
64.8
作者：
Feng, Feng;Yang, Fan;Zhou, Jian-Min
通讯作者：
Zhou, Jian-Min
DOI：
10.1073/pnas.68.12.2949
发表时间：
1971-01-01
影响因子：
11.1
作者：
BROWN, MS;SEGAL, A;STADTMAN, ER
通讯作者：
STADTMAN, ER
DOI：
10.1126/science.1193844
发表时间：
2010-09-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cui J;Yao Q;Li S;Ding X;Lu Q;Mao H;Liu L;Zheng N;Chen S;Shao F
通讯作者：
Shao F
影响因子：
4.8
作者：
Chou, Yang-Chieh;Keszei, Alexander F. A.;Sicheri, Frank
通讯作者：
Sicheri, Frank