The HTLV-1 Tax interactome.
The HTLV-1 Tax interactome.
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DOI:
10.1186/1742-4690-5-76
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发表时间:
2008-08-14
期刊:
影响因子:
3.3
通讯作者:
Willems L
中科院分区:
文献类型:
--
作者:
Boxus M;Twizere JC;Legros S;Dewulf JF;Kettmann R;Willems L
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
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影响因子:
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通讯作者:
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影响因子:
20.3
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DOI:
10.1073/pnas.0608832104
发表时间:
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影响因子:
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作者:
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通讯作者:
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