Clinical and Genetic Correlates of Bipolar Disorder With Childhood-Onset Attention Deficit Disorder.
Clinical and Genetic Correlates of Bipolar Disorder With Childhood-Onset Attention Deficit Disorder.
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DOI：
10.3389/fpsyt.2022.884217
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发表时间：
2022
影响因子：
4.7
通讯作者：
Biernacka, Joanna M.
中科院分区：
文献类型：
--
作者：
Nunez, Nicolas A.;Coombes, Brandon J.;Romo-Nava, Francisco;Bond, David J.;Vande Voort, Jennifer;Croarkin, Paul E.;Leibman, Nicole;Gardea Resendez, Manuel;Veldic, Marin;Betcher, Hannah;Singh, Balwinder;Colby, Colin;Cuellar-Barboza, Alfredo;Prieto, Miguel;Moore, Katherine M.;Ozerdem, Aysegul;McElroy, Susan L.;Frye, Mark A.;Biernacka, Joanna M.
双相情感障碍（BD）合并注意缺陷多动障碍（ADHD）与不利的病程相关。我们的目的是确定双相障碍伴和不伴ADHD的潜在临床和遗传相关性。在梅奥诊所双相生物库登记的双相障碍患者（N = 2198）中，我们确定了在儿童期诊断为ADHD的患者（BD+cADHD, N = 350）、成人发病的注意缺陷症状（BD+aAD, N = 254）和无ADHD的患者（N = 1594）。我们使用线性或逻辑回归对年龄、性别和招募地点进行调整。对于基因型患者（N = 1443），采用logistic回归比较双相障碍组和非双相障碍对照组（N = 777）的ADHD和双相障碍多基因风险评分（PRSs）。与非adhd双相障碍组相比，BD+cADHD患者更年轻，男性更常见，同时出现焦虑和物质使用障碍的人数更多（均p < 0.001）。此外，BD+cADHD患者对锂和拉莫三嗪的反应较差（p = 0.005和p = 0.007）。在PRS分析中，与非双相障碍对照组相比，所有双相障碍患者亚群患双相障碍和多动症的遗传风险更高（所有比较p < 0.001）。BD+cADHD患者的ADHD-PRS高于非adhd BD患者（p = 0.012）。然而，BD+aAD患者没有证据表明ADHD-PRS高于非adhd BD患者（p = 0.38）。BD+cADHD与更多的合并症和对情绪稳定治疗的反应降低有关。BD+cADHD组较高的ADHD PRS可能反映了遗传因素对ADHD症状早期表现的更大影响。
Bipolar disorder (BD) with co-occurring attention deficit-hyperactivity disorder (ADHD) is associated with an unfavorable course of illness. We aimed to identify potential clinical and genetic correlates of BD with and without ADHD. Among patients with BD (N = 2,198) enrolled in the Mayo Clinic Bipolar Biobank we identified those with ADHD diagnosed in childhood (BD+cADHD; N = 350), those with adult-onset attention deficit symptoms (BD+aAD; N = 254), and those without ADHD (N = 1,594). We compared the groups using linear or logistic regression adjusting for age, sex, and recruitment site. For genotyped patients (N = 1,443), logistic regression was used to compare ADHD and BD polygenic risk scores (PRSs) between the BD groups, as well as to non-BD controls (N = 777). Compared to the non-ADHD BD group, BD+cADHD patients were younger, more often men and had a greater number of co-occurring anxiety and substance use disorders (all p < 0.001). Additionally, BD+cADHD patients had poorer responses to lithium and lamotrigine (p = 0.005 and p = 0.007, respectively). In PRS analyses, all BD patient subsets had greater genetic risk for BD and ADHD when compared to non-BD controls (p < 0.001 in all comparisons). BD+cADHD patients had a higher ADHD-PRS than non-ADHD BD patients (p = 0.012). However, BD+aAD patients showed no evidence of higher ADHD-PRS than non-ADHD BD patients (p = 0.38). BD+cADHD was associated with a greater number of comorbidities and reduced response to mood stabilizing treatments. The higher ADHD PRS for the BD+cADHD group may reflect a greater influence of genetic factors on early presentation of ADHD symptoms.
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影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
6.6
作者：
Perugi, G.;Ceraudo, G.;Dell'Osso, L.
通讯作者：
Dell'Osso, L.
影响因子：
7.3
作者：
Karaahmet, Elif;Konuk, Numan;Atik, Levent
通讯作者：
Atik, Levent
影响因子：
10.6
作者：
Nierenberg, AA;Miyahara, S;Sachs, GS
通讯作者：
Sachs, GS
DOI：
10.1177/070674378703200711
发表时间：
1987-10-01
影响因子：
4
作者：
LAROCHE, C;SHEINER, R;CHEIFETZ, P
通讯作者：
CHEIFETZ, P