ATP during early bladder stretch is important for urgency in detrusor overactivity patients.
ATP during early bladder stretch is important for urgency in detrusor overactivity patients.
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DOI：
10.1155/2014/204604
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发表时间：
2014
影响因子：
--
通讯作者：
Moore KH
中科院分区：
文献类型：
--
作者：
Cheng Y;Mansfield KJ;Allen W;Chess-Williams R;Burcher E;Moore KH
ATP是逼尿肌过度活跃（DO）女性急症的重要中介。为了了解与对照组相比，DO患者不同程度的膀胱拉伸对ATP释放的影响，在女性DO患者和对照组中，在膀胱术中收集了顺序等比，并测量了膀胱填充程度的ATP释放。在DO组和对照组中，ATP在膀胱充盈过程中被诱导释放，这表明拉伸刺激了ATP的进一步释放。然而，在灌浆早期（200 mL），腔内ATP浓度已经很高，甚至高于灌浆后期（400 mL和最大膀胱容量MCC），这表明在DO和对照中，在灌浆早期（200 mL）诱导了大量ATP释放。在DO中，低第一排空欲望（FDV）组（≤200 mL）在200 mL时ATP释放量显著高于高第一排空欲望（FDV）组（bb0 200 mL）；这可能表明早期拉伸时的ATP释放可能在DO的急迫性（早期感觉）中起重要作用。排尿后ATP浓度保持不变，提示排尿不会进一步诱导ATP释放到腔内液中。
ATP is an important mediator of urgency in women with detrusor overactivity (DO). In order to understand how different degrees of bladder stretch elicited ATP release in DO patients compared with controls, sequential aliquots were collected during cystometry and ATP release was measured at each degree of bladder filling, in female patients with DO and controls. In both DO and control groups, ATP release was induced during bladder filling, suggesting that stretch stimulated further ATP release. However, the luminal ATP concentrations were already high at early filling stage (200 mL), which was even greater than those at the later filling stages (400 mL and maximum cystometric capacity, MCC), indicating that a substantial ATP release has been induced during early filling (200 mL) in both DO and controls. In DO, ATP release at 200 mL was significantly higher in those with low first desire to void (FDV) (≤200 mL) than in those with higher FDV (>200 mL); this may suggest that ATP release at early stretch may play an important role in urgency (early sensation) in DO. ATP concentrations remained unchanged after voiding, suggesting that voiding did not further induce ATP release into intraluminal fluid.
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