A model to estimate insulin sensitivity in dairy cows.
A model to estimate insulin sensitivity in dairy cows.
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DOI：
10.1186/1751-0147-49-29
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发表时间：
2007-10-11
影响因子：
2.1
通讯作者：
Holtenius K
中科院分区：
文献类型：
--
作者：
Holtenius P;Holtenius K
能量代谢的胰岛素调节受损被认为是代谢紊乱的病因学关键组成部分。因此，胰岛素敏感性的研究方法是高度热门的。有明确的迹象表明，胰岛素敏感性降低有助于代谢紊乱，尤其是在肥胖的泌乳奶牛中。直接测量胰岛素敏感性是费力的，不适合流行病学研究。因此，我们采用了一种最初为人类开发的间接方法来估计奶牛的胰岛素敏感性。该方法“修订的定量胰岛素敏感性检查指数”（RQUICKI）基于血糖、胰岛素和游离脂肪酸（FFA）的血浆浓度，它与人群中胰岛素敏感性的不同估计值产生良好的线性相关性。我们假设RQUICKI方法可用作泌乳奶牛胰岛素功能的指标。我们计算RQUICKI在237个明显健康的奶牛从20个商业牛群。纳入的所有奶牛均处于前15周泌乳期。RQUICKI不受哺乳期前15周内发生的能量代谢的顺势适应的影响。在一组24头试验奶牛中，为了获得分娩时不同的身体状况而饲喂，在泌乳早期，身体状况评分较高的奶牛的RQUICKI较低，表明肥胖奶牛的胰岛素功能受到干扰。结果表明，RQUICKI可用于识别胰岛素功能紊乱的泌乳奶牛。
Impairment of the insulin regulation of energy metabolism is considered to be an etiologic key component for metabolic disturbances. Methods for studies of insulin sensitivity thus are highly topical. There are clear indications that reduced insulin sensitivity contributes to the metabolic disturbances that occurs especially among obese lactating cows. Direct measurements of insulin sensitivity are laborious and not suitable for epidemiological studies. We have therefore adopted an indirect method originally developed for humans to estimate insulin sensitivity in dairy cows. The method, "Revised Quantitative Insulin Sensitivity Check Index" (RQUICKI) is based on plasma concentrations of glucose, insulin and free fatty acids (FFA) and it generates good and linear correlations with different estimates of insulin sensitivity in human populations. We hypothesized that the RQUICKI method could be used as an index of insulin function in lactating dairy cows. We calculated RQUICKI in 237 apparently healthy dairy cows from 20 commercial herds. All cows included were in their first 15 weeks of lactation. RQUICKI was not affected by the homeorhetic adaptations in energy metabolism that occurred during the first 15 weeks of lactation. In a cohort of 24 experimental cows fed in order to obtain different body condition at parturition RQUICKI was lower in early lactation in cows with a high body condition score suggesting disturbed insulin function in obese cows. The results indicate that RQUICKI might be used to identify lactating cows with disturbed insulin function.
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影响因子：
2.1
作者：
Rose, MT;Obara, Y;Takahashi, Y
通讯作者：
Takahashi, Y
影响因子：
3.5
作者：
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Holtenius, K
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7
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Nugent, A
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作者：
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Sandgren, CH
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通讯作者：
Blum, JW