Regulation of Host Defense Peptide Synthesis by Polyphenols.
Regulation of Host Defense Peptide Synthesis by Polyphenols.
复制标题
调节多酚对宿主防御肽合成。
DOI：
10.3390/antibiotics12040660
复制
发表时间：
2023-03-28
影响因子：
4.8
通讯作者：
Zhang, Guolong
中科院分区：
文献类型：
--
作者：
Tobin, Isabel;Zhang, Guolong
抗菌素耐药性的上升产生了对疾病控制和预防的抗生素替代战略的迫切需要。宿主防御肽(HDPs)是天然免疫系统的重要组成部分，具有抗菌和免疫调节作用。一种以宿主为导向的刺激内源性HDPs合成的方法已成为治疗感染的一种有前途的解决方案，其产生抗菌素耐药性的风险最低。在被鉴定为HDP合成诱导剂的各种化合物中，多酚是植物自然产生的次生代谢物，其特征是存在多个苯酚单位。除了众所周知的抗氧化和抗炎活性外，多种多酚已被证明能刺激不同动物物种的HDP合成。本文综述了多酚类物质调节HDP合成的体内外证据。并对多酚诱导HDP基因表达的机制进行了讨论。天然多酚作为控制和预防传染病的潜在抗生素替代品值得进一步研究。
The rise of antimicrobial resistance has created an urgent need for antibiotic-alternative strategies for disease control and prevention. Host defense peptides (HDPs), which have both antimicrobial and immunomodulatory properties, are an important component of the innate immune system. A host-directed approach to stimulate the synthesis of endogenous HDPs has emerged as a promising solution to treat infections with a minimum risk for developing antimicrobial resistance. Among a diverse group of compounds that have been identified as inducers of HDP synthesis are polyphenols, which are naturally occurring secondary metabolites of plants characterized by the presence of multiple phenol units. In addition to their well-known antioxidant and anti-inflammatory activities, a variety of polyphenols have been shown to stimulate HDP synthesis across animal species. This review summarizes both the in vitro and in vivo evidence of polyphenols regulating HDP synthesis. The mechanisms by which polyphenols induce HDP gene expression are also discussed. Natural polyphenols warrant further investigation as potential antibiotic alternatives for the control and prevention of infectious diseases.
登录
查看更多内容
影响因子：
5.6
作者：
通讯作者：
--
影响因子：
5.2
作者：
Dijksteel GS;Ulrich MMW;Middelkoop E;Boekema BKHL
通讯作者：
Boekema BKHL
DOI：
10.1016/j.bbrc.2005.05.073
发表时间：
2005-07-22
影响因子：
3.1
作者：
Deby-Dupont, G;Mouithys-Mickalad, A;Deby, C
通讯作者：
Deby, C
影响因子：
5.7
作者：
de Barros PP;Rossoni RD;Garcia MT;Kaminski VL;Loures FV;Fuchs BB;Mylonakis E;Junqueira JC
通讯作者：
Junqueira JC
影响因子：
4.1
作者：
Balogun, E;Hoque, M;Motterlini, R
通讯作者：
Motterlini, R