Identifying early changes in myocardial microstructure in hypertensive heart disease.
Identifying early changes in myocardial microstructure in hypertensive heart disease.
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DOI：
10.1371/journal.pone.0097424
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Cheng S
中科院分区：
文献类型：
--
作者：
Hiremath P;Bauer M;Aguirre AD;Cheng HW;Unno K;Patel RB;Harvey BW;Chang WT;Groarke JD;Liao R;Cheng S
从健康心肌到高血压性心脏病的转变的特征在于心肌组织微结构的一系列尚不清楚的变化。心肌纤维的方向和完整性的增量改变可以使用先进的超声图像分析进行评估。我们使用了一种改进的算法来研究左心室心肌的微观结构的基础上的反射强度在B型超声心动图图像上的心肌-心包界面的分析。我们评估了这种新型算法可以在多大程度上区分人类正常心肌和高血压心脏病以及后负荷抵抗小鼠模型。该算法显着区分个体与单纯原发性高血压（N = 30）和健康对照组（N = 28），即使在调整年龄和性别（P = 0.025）。 与对照组相比，高血压患者的相对室壁厚度有增加的趋势（P = 0.08），但两组之间的左心室质量（P = 0.98）或总室壁厚度（P = 0.37）无差异。 在小鼠中，术后7周超声心动图显示，与左心室质量（P =0.053）相比，算法测量值（P=0.026）更清楚地区分了接受固定主动脉结扎术、临时主动脉结扎术或假手术的动物组。 基于超声信号强度分析，一种新的成像算法提供了一种可访问的，非侵入性的措施，似乎区分正常的左心室微结构心肌暴露于慢性后负荷应力。该算法可以代表在疾病进展过程中早期发生的心肌变化的特别敏感的测量。
The transition from healthy myocardium to hypertensive heart disease is characterized by a series of poorly understood changes in myocardial tissue microstructure. Incremental alterations in the orientation and integrity of myocardial fibers can be assessed using advanced ultrasonic image analysis. We used a modified algorithm to investigate left ventricular myocardial microstructure based on analysis of the reflection intensity at the myocardial-pericardial interface on B-mode echocardiographic images. We evaluated the extent to which the novel algorithm can differentiate between normal myocardium and hypertensive heart disease in humans as well as in a mouse model of afterload resistance. The algorithm significantly differentiated between individuals with uncomplicated essential hypertension (N = 30) and healthy controls (N = 28), even after adjusting for age and sex (P = 0.025). There was a trend in higher relative wall thickness in hypertensive individuals compared to controls (P = 0.08), but no difference between groups in left ventricular mass (P = 0.98) or total wall thickness (P = 0.37). In mice, algorithm measurements (P = 0.026) compared with left ventricular mass (P = 0.053) more clearly differentiated between animal groups that underwent fixed aortic banding, temporary aortic banding, or sham procedure, on echocardiography at 7 weeks after surgery. Based on sonographic signal intensity analysis, a novel imaging algorithm provides an accessible, non-invasive measure that appears to differentiate normal left ventricular microstructure from myocardium exposed to chronic afterload stress. The algorithm may represent a particularly sensitive measure of the myocardial changes that occur early in the course of disease progression.
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成人生活过程中的血压跟踪：弗雷明汉心脏研究中的模式和相关性。
DOI：
10.1161/hypertensionaha.112.201780
发表时间：
2012-12
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Cheng S;Xanthakis V;Sullivan LM;Vasan RS
通讯作者：
Vasan RS
影响因子：
5.8
作者：
Aghini-Lombardi, Fabrizio;Di Bello, Vitantoni;Pinchera, Aldo
通讯作者：
Pinchera, Aldo
影响因子：
8.3
作者：
Hunt, KJ;Evans, GW;Heiss, G
通讯作者：
Heiss, G
影响因子：
3.7
作者：
Bauer M;Metzler R
通讯作者：
Metzler R
影响因子：
20.1
作者：
Bauer M;Cheng S;Jain M;Ngoy S;Theodoropoulos C;Trujillo A;Lin FC;Liao R
通讯作者：
Liao R