Association between fibrinogen-to-albumin ratio and the presence and severity of coronary artery disease in patients with acute coronary syndrome.
Association between fibrinogen-to-albumin ratio and the presence and severity of coronary artery disease in patients with acute coronary syndrome.
复制标题
DOI：
10.1186/s12872-021-02400-z
复制
发表时间：
2021-12-07
影响因子：
2.1
通讯作者：
Han D
中科院分区：
文献类型：
--
作者：
Duan Z;Luo C;Fu B;Han D
虽然血浆纤维蛋白原和白蛋白水平已被证明与冠心病（CHD）有关，但纤维蛋白原与白蛋白比（FAR）与急性冠脉综合征（ACS）之间的关系尚未得到充分的研究。本研究的目的是探讨FAR与ACS患者冠心病的存在和严重程度之间的关系。共有1575名接受冠状动脉造影（CAG）的患者被纳入研究。患者分为ACS组和对照组。以Gensini评分、冠脉病变数及有无心肌梗死（MI）判断ACS的严重程度。数据显示，ACS组FAR水平高于对照组（81.20±35.45比72.89±20.24,P < 0.001）。亚组分析结果显示，Gensini评分高组、心肌梗死组和多支血管狭窄组的FAR值均高于匹配亚组。校正混杂因素后，FAR仍与ACS的存在及严重程度独立相关（MI OR 2.097, 95%CI 1.430-3.076; High GS OR 2.335, 95%CI 1.567-3.479；多血管病变OR 2.088, 95%CI 1.439-3.030; P < 0.05）。FAR水平与ACS患者冠状动脉疾病的存在和严重程度独立相关。此外，FAR作为一种更方便、快速的生物学指标，可能为预测ACS的存在和严重程度提供新的思路。在线版本包含补充材料，可在10.1186/s12872-021-02400-z获得。
Although the levels of plasma fibrinogen and albumin have been proven to be in relation to coronary heart disease (CHD), the association between fibrinogen-to-albumin ratio (FAR) and acute coronary syndrome (ACS) has not been adequately investigated. The aim of this study is to investigate the relationship between FAR and the presence and severity of CHD in patients with ACS. A total of 1575 individuals who received coronary angiography (CAG) were enrolled. Patients were divided into the ACS group and the control group. The severity of ACS was determined by Gensini score, number of diseased coronary artery and the presence of myocardial infarction (MI). Data showed that the level of FAR in ACS group was higher than in the control group (81.20 ± 35.45 vs. 72.89 ± 20.24, P < 0.001). The results from subgroup analysis indicated that the values of FAR in the high Gensini score group, MI group and multiple-vessel stenosis group were higher than the matched subgroups. After adjustment for confounders, FAR was still independently related to the presence and severity of ACS (MI OR 2.097, 95%CI 1.430–3.076; High GS: OR 2.335, 95%CI 1.567–3.479; multiple-vessel disease: OR 2.088, 95%CI 1.439–3.030; P < 0.05). The levels of FAR are independently associated with the presence and the severity of coronary artery disease in patients with ACS. Furthermore, FAR, as a more convenient and rapid biological indicator, may provide a new idea for predicting the presence and severity of ACS. The online version contains supplementary material available at 10.1186/s12872-021-02400-z.
登录
查看更多内容
影响因子：
2.9
作者：
Tabakci, Mehmet Mustafa;Gerin, Fethullah;Kargin, Ramazan
通讯作者：
Kargin, Ramazan
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
19.6
作者：
Joles, JA;WillekesKoolschijn, N;Koomans, HA
通讯作者：
Koomans, HA
影响因子：
3.3
作者：
Kurtul, Alparslan;Yarlioglues, Mikail;Aksoy, Ozlem
通讯作者：
Aksoy, Ozlem
影响因子：
5.8
作者：
GRESELE, P;DECKMYN, H;VERMYLEN, J
通讯作者：
VERMYLEN, J