Plasma inflammation-related biomarkers are associated with intrinsic capacity in community-dwelling older adults.
Plasma inflammation-related biomarkers are associated with intrinsic capacity in community-dwelling older adults.
复制标题
等离子体炎症相关的生物标志物与社区居民老年人的内在能力有关。
DOI：
10.1002/jcsm.13163
复制
发表时间：
2023-04
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
炎症与内在能力（IC）（身体和精神能力的复合体）之间的关系仍不清楚。我们的研究旨在调查老年人血浆炎症相关生物标志物与 IC 之间的横向和纵向关联。多域阿尔茨海默病预防试验 (MAPT) 的二次分析包括 1238 名社区居住的老年人，并对 12 至 60 个月大的 IC 进行了评估。第 12 个月时测量血浆 C 反应蛋白 (CRP)、白细胞介素 6 (IL-6)、肿瘤坏死因子受体 1 (TNFR-1)、单核细胞趋化蛋白 1 (MCP-1) 和生长分化因子 15 (GDF-15)。 IC 被操作为 0 到 100 之间的分数，源自四个领域：认知、简易精神状态检查；运动、短体能电池；心理、老年抑郁量表；和活力，握力。在子样本 (n = 535) 中研究了五域 IC 评分（加上感觉），并进行了 1 年随访作为探索性结果。 1238 名参与者的平均年龄为 76.2 岁（SD = 4.3）； 63.7%为女性。他们最初的四域 IC 分数平均为 78.9 分 (SD = 9.3)，每年下降 1.17 分 (95% CI = -1.30 至 -1.05；P < 0.001)。在控制年龄、性别、MAPT 组分配和教育水平后，我们观察到较低基线 IC 与较高 CRP、IL-6、TNFR-1 和 GDF-15 之间存在显着相关性 [CRP：调整后 β (95% CI) = -1.56（-2.64 至 -0.48）； P = 0.005； IL-6：调整后的β=-3.16（-4.82至-1.50）； P < 0.001； TNFR-1：调整后的β=-6.86（-10.25至-3.47）； P < 0.001； GDF-15：调整后的β=−7.07（−10.02至−4.12）； P < 0.001]。较高的 TNFR-1、MCP-1 和 GDF-15 与 4 年内四结构域 IC 下降较快相关 [TNFR-1：调整后的 β (95% CI) = -1.28（-2.29 至 -0.27）； P = 0.013； MCP-1：调整后的β=−1.33（−2.24至−0.42）； P = 0.004； GDF-15：调整后的β=−1.42（−2.26 至−0.58）； P = 0.001]。没有一个生物标志物与五域 IC 下降显着相关。炎症与老年人较低的 IC 相关。在所有血浆生物标志物中，TNFR-1 和 GDF-15 在横截面和纵向水平上与 IC 一致相关。
How inflammation relates to intrinsic capacity (IC), the composite of physical and mental capacities, remains undefined. Our study aimed to investigate the cross‐sectional and longitudinal associations between plasma inflammation‐related biomarkers and IC in older adults. This secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) included 1238 community‐dwelling older individuals with IC assessments from 12 to 60 months. Plasma C‐reactive protein (CRP), interleukin‐6 (IL‐6), tumour necrosis factor receptor‐1 (TNFR‐1), monocyte chemoattractant protein‐1 (MCP‐1) and growth differentiation factor‐15 (GDF‐15) were measured at 12 months. IC was operationalized as a score ranging from 0 to 100, derived from four domains: cognition, Mini‐Mental State Examination; locomotion, Short Physical Performance Battery; psychological, Geriatric Depression Scale; and vitality, handgrip strength. A five‐domain IC score (plus sensory) was investigated in a subsample (n = 535) with a 1‐year follow‐up as an exploratory outcome. The mean age of the 1238 participants was 76.2 years (SD = 4.3); 63.7% were female. Their initial four‐domain IC scores averaged 78.9 points (SD = 9.3), with a yearly decline of 1.17 points (95% CI = −1.30 to −1.05; P < 0.001). We observed significant associations of lower baseline IC with higher CRP, IL‐6, TNFR‐1 and GDF‐15, after controlling age, sex, MAPT group allocation and educational level [CRP: adjusted β (95% CI) = −1.56 (−2.64 to −0.48); P = 0.005; IL‐6: adjusted β = −3.16 (−4.82 to −1.50); P < 0.001; TNFR‐1: adjusted β = −6.86 (−10.25 to −3.47); P < 0.001; GDF‐15: adjusted β = −7.07 (−10.02 to −4.12); P < 0.001]. Higher TNFR‐1, MCP‐1 and GDF‐15 were associated with faster decline in four‐domain IC over 4 years [TNFR‐1: adjusted β (95% CI) = −1.28 (−2.29 to −0.27); P = 0.013; MCP‐1: adjusted β = −1.33 (−2.24 to −0.42); P = 0.004; GDF‐15: adjusted β = −1.42 (−2.26 to −0.58); P = 0.001]. None of the biomarkers was significantly associated with the five‐domain IC decline. Inflammation was associated with lower IC in older adults. Among all plasma biomarkers, TNFR‐1 and GDF‐15 were consistently associated with IC at the cross‐sectional and longitudinal levels.
登录
查看更多内容
DOI：
10.1093/gerona/gln038
发表时间：
2009-04-01
影响因子：
5.1
作者：
Brinkley, Tina E.;Leng, Xiaoyan;Nicklas, Barbara J.
通讯作者：
Nicklas, Barbara J.
影响因子：
3.9
作者：
Giudici, Kelly Virecoulon;Barreto, Philipe de Souto;Coley, Nicola
通讯作者：
Coley, Nicola
影响因子：
6.6
作者：
Jin, Hye Jin;Lee, Hyang Ju;Kim, Seong Who
通讯作者：
Kim, Seong Who
影响因子：
4.3
作者：
Adela R;Banerjee SK
通讯作者：
Banerjee SK
DOI：
10.1038/s41569-018-0064-2
发表时间：
2018-09
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Ferrucci L;Fabbri E
通讯作者：
Fabbri E