Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: report from the US Pediatric Multiple Sclerosis Network.
Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: report from the US Pediatric Multiple Sclerosis Network.
复制标题
DOI：
10.1177/1352458514527862
复制
发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
US Network of Pediatric MS Centers
中科院分区：
文献类型：
--
作者：
Charvet LE;O'Donnell EH;Belman AL;Chitnis T;Ness JM;Parrish J;Patterson M;Rodriguez M;Waubant E;Weinstock-Guttman B;Krupp LB;US Network of Pediatric MS Centers
大约三分之一的儿童期MS患者存在认知障碍。关于他们的认知功能随着时间的推移而发生的变化，我们知之甚少。认知功能随时间的变化是通过美国儿科MS中心网络在迄今为止最大的儿科队列中测量的。67名患有儿童MS（n=62）或临床孤立综合征（CIS，n=5）的个体，年龄范围为8至17岁（平均年龄± SD = 14.37 ± 2.02），在平均1.64 ± 0.63年后完成了初始和随访神经心理学测试。九项测试测量一般智力，注意力和工作记忆，言语记忆，视觉整合，语言和执行功能。基线时的损伤率（有三分之一或以上的评分在损伤范围内）为37%，随访时为33%。通常受损的测试是视觉整合，快速处理和注意力的测量。大多数测试没有下降超过两年。在具体措施方面没有明确的变化模式。研究结果表明，在很短的时间内，可以出现认知能力指标的稳定甚至改善。而不是导致下降，儿科MS可能会阻止预期的年龄相关的收益。
Approximately one-third of those with pediatric-onset MS experience cognitive impairment. Less is known concerning their change in cognitive functioning over time. Changes in cognitive function over time were measured in the largest pediatric cohort to date through the U.S. Network of Pediatric MS Centers. 67 individuals with pediatric MS (n=62) or clinically isolated syndrome (CIS, n=5), ranging from 8 to 17 years of age (mean age ± SD = 14.37 ± 2.02) completed initial and followup neuropsychological testing after an average of 1.64 ± 0.63 years. The nine tests administered measure general intellect, attention and working memory, verbal memory, visuomotor integration, language, and executive functioning. Rate of impairment (having one-third or more scores in the impaired range) was 37% at baseline and 33% at follow-up. Tests commonly impaired were measures of visuomotor integration, speeded processing, and attention. Most tested did not decline over two years. There was no clear pattern of change on specific measures. Findings suggest that over short timeframes, stable or even improved performances on measures of cognitive ability can occur. Rather than leading to decline, pediatric MS may instead prevent expected age-related gains.
登录
查看更多内容
影响因子：
--
作者：
Qu, ZX;Pliskin, N;Arnason, BGW
通讯作者：
Arnason, BGW
影响因子：
1.9
作者：
Julian L;Serafin D;Charvet L;Ackerson J;Benedict R;Braaten E;Brown T;O'Donnell E;Parrish J;Preston T;Zaccariello M;Belman A;Chitnis T;Gorman M;Ness J;Patterson M;Rodriguez M;Waubant E;Weinstock-Guttman B;Yeh A;Krupp LB;Network of Pediatric MS Centers of Excellence
通讯作者：
Network of Pediatric MS Centers of Excellence
影响因子：
9.9
作者：
MacAllister, WS;Belman, AL;Krupp, LB
通讯作者：
Krupp, LB
影响因子：
5.9
作者：
JACOBSON, NS;TRUAX, P
通讯作者：
TRUAX, P
影响因子：
3.9
作者：
Smerbeck, A. M.;Parrish, J.;Benedict, R. H. B.
通讯作者：
Benedict, R. H. B.