Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network.
Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network.
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DOI：
10.1177/0883073812464816
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发表时间：
2013-01
影响因子：
1.9
通讯作者：
Network of Pediatric MS Centers of Excellence
中科院分区：
文献类型：
--
作者：
Julian L;Serafin D;Charvet L;Ackerson J;Benedict R;Braaten E;Brown T;O'Donnell E;Parrish J;Preston T;Zaccariello M;Belman A;Chitnis T;Gorman M;Ness J;Patterson M;Rodriguez M;Waubant E;Weinstock-Guttman B;Yeh A;Krupp LB;Network of Pediatric MS Centers of Excellence
在迄今为止研究的最大样本中，我们测量了患有儿童多发性硬化症(n=187)和临床孤立综合征(n=44)的儿童和青少年的认知功能。参与者是从六个美国儿科多发性硬化症卓越中心连续招募的。受试者平均年龄14.8±2.6岁，平均病程1.9±2.2年。共有65名(35%)患有多发性硬化症的儿童和8名(18%)患有临床孤立综合征的儿童符合认知障碍的标准。最常见的领域是精细运动协调(54%)、视觉运动整合(50%)和信息处理速度加快(35%)。多发性硬化症的诊断(优势比=3.60，可信区间=1.07，12.36，P=0.04)和整体神经功能障碍(优势比=1.47，可信区间=1.10，2.10，P=0.03)是认知障碍的唯一独立预测因素。认知障碍可能发生在这些患者的早期，及时识别对他们的护理至关重要。
In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n =187) as well as those with clinically isolated syndrome (n =44). Participants were consecutively enrolled from six United States PediatricMultiple Sclerosis Centers of Excellence. Participants had amean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.
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影响因子：
9.9
作者：
MacAllister, WS;Belman, AL;Krupp, LB
通讯作者：
Krupp, LB
影响因子：
9.9
作者：
Ross, K. A.;Schwebel, D. C.;Ackerson, J.
通讯作者：
Ackerson, J.
影响因子：
9.9
作者：
Amato, M. P.;Goretti, B.;Trojano, M.
通讯作者：
Trojano, M.
DOI：
10.1177/1352458508101933
发表时间：
2009-05-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Chitnis, T.;Glanz, B.;Healy, B.
通讯作者：
Healy, B.
影响因子：
5.8
作者：
Smerbeck, A. M.;Parrish, J.;Benedict, R. H. B.
通讯作者：
Benedict, R. H. B.