A Study on Gentiana dahurica Fisch Ethanol Extract Alleviating Alcoholic Liver Disease in Mice: A Metabolomic Analysis of the Liver.
A Study on Gentiana dahurica Fisch Ethanol Extract Alleviating Alcoholic Liver Disease in Mice: A Metabolomic Analysis of the Liver.
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白龙胆乙醇提取物缓解小鼠酒精性肝病的研究：肝脏代谢组学分析
DOI：
10.1155/2021/5569538
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Jin L
中科院分区：
文献类型：
--
作者：
Cao H;Guo Y;Jin L
我们在我们先前的研究中阐明了Gentiana Dahurica Fisch乙醇提取物（GDEE）的肝保护作用，我们在本研究中借助代谢组技术进一步揭示了该机制。由代谢组学分析。使用质谱法（MS）/MS分析确定。结果表明，这些组可以通过PCA和OPLS-DA分析来区分。肝脏代谢物的特征。 ALD具有多坐马和多道路的特征。
We clarified the hepatoprotective effect of Gentiana dahurica Fisch ethanol extract (GDEE) in our previous study, and we further revealed the mechanism with the help of metabolomics technology in this study. The livers from Control group, Alcohol group, and Alcohol + GDEE group were analyzed by metabolomics. The metabolites in the liver were separated by ultra-high-performance liquid chromatography (UHPLC) and were tentatively identified using mass spectrometry (MS)/MS analysis. Differential metabolites were defined with VIP > 1 and P < 0.05. Principal component analysis (PCA) and orthogonal partial least square discriminant analysis (OPLS-DA) were applied to analyze differences among these groups. The results showed that the groups could be clearly distinguished by PCA and OPLS-DA analysis. Alcohol and GDEE could change the overall profile of liver metabolites. Alterations in liver tissues of ALD mice induced by alcohol were mainly involved in the dipeptides, purine and pyrimidine metabolism and glucose and lipid metabolism, which could be partly affected by GDEE. This study revealed that the mechanism of GDEE in alleviating ALD had the characteristics of multitarget and multipathway.
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DOI：
10.1016/0167-4838(87)90170-1
发表时间：
1987-12-18
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
CHIEW, YE;OSULLIVAN, WJ;LEE, CS
通讯作者：
LEE, CS
影响因子：
4
作者：
Adeva-Andany MM;Pérez-Felpete N;Fernández-Fernández C;Donapetry-García C;Pazos-García C
通讯作者：
Pazos-García C
DOI：
10.1155/2020/4543761
发表时间：
2020
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Niu JT;Cao R;Si XL;Bian TT;Xin ED;Li YF;Yan XK
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Yan XK
影响因子：
50.3
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Hsieh JJ
影响因子：
6.7
作者：
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通讯作者：
Ahmed, Aijaz