Meta-analysis of stem cell transplantation for reflex hypersensitivity after spinal cord injury.
Meta-analysis of stem cell transplantation for reflex hypersensitivity after spinal cord injury.
复制标题
干细胞移植治疗脊髓损伤后反射性超敏反应的荟萃分析
DOI：
10.1016/j.neuroscience.2017.06.027
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发表时间：
2017-11-05
期刊：
影响因子：
3.3
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Chen X;Xue B;Li Y;Song C;Jia P;Ren X;Zang W;Wang J
干细胞已被用于治疗脊髓损伤(SCI)的新策略，但干细胞移植对脊髓损伤后神经病理性疼痛的影响尚不清楚。目前的荟萃分析评估了干细胞移植对脊髓损伤后神经病理性疼痛的影响。我们首先在网上检索PubMed、Web of Science、中国学术期刊全文数据库和万方数据，进行随机对照试验，比较干细胞移植和赋形剂治疗脊髓损伤后神经病理性疼痛的啮齿动物模型。使用Cochrane Reviser‘s Handbook 5.1.0进行质量评估，并使用Revman 5.3进行Meta分析。然后，我们建立了大鼠脊髓损伤模型，并移植了骨髓间充质干细胞来验证荟萃分析的结果。12个随机对照试验(n=354只动物)纳入我们的荟萃分析，并按亚组进行划分，包括种类、行为测量的时间和脊髓损伤后的移植时间。这12项研究的亚组分析表明，干细胞处理的动物比赋形剂组有更高的机械反射阈值，在大鼠和小鼠中都有显著差异。热戒断潜伏期在小鼠亚组中显示相同的结果，但在大鼠亚组中不同。此外，间充质干细胞移植是一种有效的治疗方法，但不能缓解大鼠的热反射超敏反应。在脊髓损伤后3天或7天进行移植，效果良好。干细胞移植可减轻脊髓损伤后大鼠和小鼠的机械反射超敏反应和小鼠的热反射超敏反应。
Stem cells have been used in novel therapeutic strategies for spinal cord injury (SCI), but the effect of stem cell transplantation on neuropathic pain after SCI is unclear. The current meta-analysis evaluates the effects of stem cell transplantation on neuropathic pain after SCI. We first conducted online searches of PubMed, Web of Science, China Academic Journals Full-text Database, and Wanfang Data for randomized controlled trials that compared stem cell transplantation and vehicle treatments in rodent models of neuropathic pain after SCI. Quality assessment was performed using Cochrane Reviewer’s Handbook 5.1.0, and meta-analysis was conducted with RevMan 5.3. Then, we developed a rat model of SCI and transplanted bone marrow mesenchymal stem cells to verify meta-analysis results. Twelve randomized, controlled trials (n = 354 total animals) were included in our meta-analysis and divided by subgroups, including species, timing of behavioral measurements, and transplantation time after SCI. Subgroup analysis of these 12 studies indicated that stem cell-treated animals had a higher mechanical reflex threshold than vehicle groups, with a significant difference in both rats and mice. The thermal withdrawal latency showed the same results in mouse subgroups, but not in rat subgroups. In addition, mesenchymal stem cell transplantation was an effective treatment for mechanical, but not thermal reflex hypersensitivity relief in rats. Transplantation showed a positive effect when carried out at 3 or 7 days post-SCI. Stem cell transplantation alleviates mechanical reflex hypersensitivity in rats and mice and thermal reflex hypersensitivity in mice after SCI.
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影响因子：
7.5
作者：
Amemori T;Ruzicka J;Romanyuk N;Jhanwar-Uniyal M;Sykova E;Jendelova P
通讯作者：
Jendelova P
DOI：
10.3344/kjp.2015.28.2.129
发表时间：
2015-04
期刊：
The Korean journal of pain
影响因子：
--
作者：
Hassanijirdehi M;Khak M;Afshari-Mirak S;Holakouie-Naieni K;Saadat S;Taheri T;Rahimi-Movaghar V
通讯作者：
Rahimi-Movaghar V
影响因子：
2.2
作者：
Donnelly, C;Eng, JJ
通讯作者：
Eng, JJ
影响因子：
7.4
作者：
Baastrup, Cathrine;Maersk-Moller, Camilla Charlotte;Finnerup, Nanna Brix
通讯作者：
Finnerup, Nanna Brix
沃顿商学院的果冻移植改善了创伤性脑损伤大鼠模型的神经功能
影响因子：
4
作者：
Cheng, Tian;Yang, Bo;Li, Dongpeng;Ma, Shanshan;Tian, Yi;Qu, Ruina;Zhang, Wenjin;Zhang, Yanting;Hu, Kai;Guan, Fangxia;Wang, Jian
通讯作者：
Wang, Jian