Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia.
Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia.
复制标题
先天性失语症患者颞上回和后扣带皮层静息态半球间功能连接性增强
DOI：
10.3389/fnins.2021.653325
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发表时间：
2021
影响因子：
4.3
通讯作者：
Wu D
中科院分区：
文献类型：
--
作者：
Jin Z;Huyang S;Jiang L;Yan Y;Xu M;Wang J;Li Q;Wu D
Interhemispheric connectivity of the two cerebral hemispheres is crucial for a broad repertoire of cognitive functions including music and language. Congenital amusia has been reported as a neurodevelopment disorder characterized by impaired music perception and production. However, little is known about the characteristics of the interhemispheric functional connectivity (FC) in amusia. In the present study, we used a newly developed voxel-mirrored homotopic connectivity (VMHC) method to investigate the interhemispheric FC of the whole brain in amusia at resting-state. Thirty amusics and 29 matched participants underwent a resting-state functional magnetic resonance imaging (fMRI) scanning. An automated VMHC approach was used to analyze the fMRI data. Compared to the control group, amusics showed increased VMHC within the posterior part of the default mode network (DMN) mainly in the posterior superior temporal gyrus (pSTG) and posterior cingulate cortex (PCC). Correlation analyses revealed negative correlations between the VMHC value in pSTG/PCC and the music perception ability among amusics. Further ROC analyses showed that the VMHC value of pSTG/PCC showed a good sensibility/specificity to differentiate the amusics from the controls. These findings provide a new perspective for understanding the neural basis of congenital amusia and imply the immature state of DMN may be a credible neural marker of amusia.
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影响因子：
1.2
作者：
Estanol, B;Mendez, A
通讯作者：
Mendez, A
影响因子：
5.7
作者：
Gracia-Tabuenca, Zeus;Moreno, Martha B.;Alcauter, Sarael
通讯作者：
Alcauter, Sarael
影响因子：
3.7
作者：
Baltes, PB;Lindenberger, U
通讯作者：
Lindenberger, U
影响因子：
2.5
作者：
Foxton, Jessica M.;Nandy, Rachel K.;Griffiths, Timothy D.
通讯作者：
Griffiths, Timothy D.
影响因子：
14.5
作者：
Albouy, Philippe;Mattout, Jeremie;Tillmann, Barbara
通讯作者：
Tillmann, Barbara