Tricyclic thiazoles are a new class of angiogenesis inhibitors.
Tricyclic thiazoles are a new class of angiogenesis inhibitors.
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DOI：
10.1016/j.bmcl.2013.02.067
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发表时间：
2013-05-01
影响因子：
2.7
通讯作者：
Liu, Jun O.
中科院分区：
文献类型：
--
作者：
Bhat, Shridhar;Shim, Joong Sup;Liu, Jun O.
Tricyclic thiazoleamine derivatives that were identified as hits in a screen against human umbilica vein endothelial cell proliferation were subjected to a structure-activity relationship study. Two structurally superimposable scaffolds—4H-thiochromeno[4,3- d]thiazol-2-amine and 5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d]thiazol-2-amine derivatives—yielded low-micromolar inhibitors, and two among them 37 and 43 also exhibited antiangiogenic activity in an endothelial tube formation assay Thus, 37 and 43 can serve as leads to develop a novel class of antiangiogenic agents.
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影响因子：
50.3
作者：
Hanahan, Douglas;Coussens, Lisa M.
通讯作者：
Coussens, Lisa M.
影响因子：
--
作者：
Griffith, EC;Su, Z;Liu, JO
通讯作者：
Liu, JO
影响因子：
158.5
作者：
Motzer, Robert J.;Hutson, Thomas E.;Figlin, Robert A.
通讯作者：
Figlin, Robert A.
影响因子：
158.5
作者：
Hurwitz, H;Fehrenbacher, L;Kabbinavar, F
通讯作者：
Kabbinavar, F
DOI：
10.1038/nrclinonc.2011.21
发表时间：
2011-03-01
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Ebos JM;Kerbel RS
通讯作者：
Kerbel RS