Mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on elevated levels of serum liver enzymes in male Japanese health check-up examinees: an exploratory cross-sectional study.
Mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on elevated levels of serum liver enzymes in male Japanese health check-up examinees: an exploratory cross-sectional study.
复制标题
DOI：
10.1186/s40101-016-0098-2
复制
发表时间：
2016-06-04
影响因子：
3.1
通讯作者：
Takashima Y
中科院分区：
文献类型：
--
作者：
Kokaze A;Yoshida M;Ishikawa M;Matsunaga N;Karita K;Ochiai H;Shirasawa T;Nanri H;Mitsui K;Hoshimo H;Takashima Y
长寿相关线粒体 DNA 5178 胞嘧啶/腺嘌呤 (Mt5178 C/A) 多态性调节咖啡摄入对高血压、血脂异常和糖耐量异常风险的影响。本研究的目的是调查 Mt5178 C/A 多态性是否改变了咖啡摄入对日本男性健康检查受试者血清肝酶水平异常升高的影响。从定期到医院进行体检的个体中选取了 421 名男性受试者（平均年龄±SD，54.1±7.7 岁）。 Mt5178 C/A 基因分型后，进行了一项横断面研究，评估 Mt5178 C/A 多态性和咖啡摄入对血清天冬氨酸转氨酶 (AST)、血清丙氨酸转氨酶 (ALT) 和血清 γ-谷氨酰转肽酶 (GGT) 水平升高的联合影响。对于患有 Mt5178C 的男性，在调整年龄、体重指数、饮酒、习惯吸烟、绿茶摄入、抗高血压治疗和抗糖尿病治疗后，血清 AST 水平升高（定义为 ≥30 U/L）；血清 ALT，定义为 ≥25 U/L；或血清 GGT 的值（定义为 ≥60 或 >51 U/L）可能取决于咖啡的摄入量（趋势的 P 值 = 0.013，趋势的 P 值 <0.001，趋势的 P 值 = 0.002，趋势的 P 值 <0.001）。另一方面，没有观察到 Mt5178A 基因型和咖啡摄入对血清肝酶水平升高的显着联合影响。目前的结果表明，Mt5178 C/A 多态性改变了咖啡摄入对日本男性健康检查受试者血清肝酶水平异常升高的影响。
Longevity-associated mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia, and abnormal glucose tolerance. The objective of this study was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on abnormally elevated levels of serum liver enzymes in male Japanese health check-up examinees. A total of 421 male subjects (mean age ± SD, 54.1 ± 7.7 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on elevated levels of serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), and serum gamma-glutamyl transpeptidase (GGT) was then conducted. For men with Mt5178C, after adjustment for age, body mass index, alcohol consumption, habitual smoking, green tea consumption, antihypertensive treatment, and antidiabetic treatment, elevated levels of serum AST, as defined as ≥30 U/L; those of serum ALT, as defined as ≥25 U/L; or those of serum GGT, as defined as ≥60 or >51 U/L, may depend on coffee consumption (P for trend = 0.013, P for trend <0.001, P for trend = 0.002, and P for trend <0.001, respectively). On the other hand, no significant joint effects of Mt5178A genotype and coffee consumption on elevated levels of serum liver enzymes were observed. The present results suggest that Mt5178 C/A polymorphism modifies the effects of coffee consumption on abnormally elevated levels of serum liver enzymes in male Japanese health check-up examinees.
影响因子：
3.7
作者：
Kokaze A;Yoshida M;Ishikawa M;Matsunaga N;Karita K;Ohtsu T;Ochiai H;Shirasawa T;Nanri H;Baba Y;Hoshino H;Takashima Y
通讯作者：
Takashima Y