NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study.
NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study.
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DOI：
10.1186/1617-9625-12-11
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发表时间：
2014
影响因子：
3.7
通讯作者：
Takashima Y
中科院分区：
文献类型：
--
作者：
Kokaze A;Yoshida M;Ishikawa M;Matsunaga N;Karita K;Ohtsu T;Ochiai H;Shirasawa T;Nanri H;Baba Y;Hoshino H;Takashima Y
据报道，NADH脱氢酶亚基-2 237亮氨酸/蛋氨酸（ND 2 -237 Leu/Met）多态性影响吸烟对呼吸功能、血脂异常风险、血清非高密度脂蛋白胆固醇水平、血液学参数和眼内压的影响。本研究的目的是调查ND 2 -237 Leu/Met多态性是否改变吸烟对日本男性健康检查受试者血清肝酶水平的影响。从定期到医院进行体检的个体中选择了共计421名男性受试者（平均年龄± SD，54.1 ± 7.7岁）。在ND 2 -237 Leu/Met基因分型后，进行了一项横断面研究，评估ND 2 -237 Leu/Met多态性和吸烟对血清天冬氨酸转氨酶水平、血清丙氨酸转氨酶（ALT）水平和血清γ-谷氨酰转移酶（GGT）水平的联合影响。ND 2 -237 Leu/Met基因型在三个吸烟状态组（从不吸烟或戒烟者、每天吸烟1-20支和每天吸烟>20支）中未观察到血清肝酶水平的统计学显著差异。然而，对于ND 2 - 237 Met男性，吸烟显著增加了血清ALT（>30 U/L）或血清GGT（≥60 U/L或>51 U/L）水平升高的风险（趋势P = 0.031，趋势P = 0.007和趋势P = 0.004）。在校正年龄、体重指数、饮酒、咖啡、抗高血压治疗和抗糖尿病治疗后，吸烟与血清ALT（>30 U/L）或血清GGT水平升高的风险之间存在显著相关性。还观察到（≥60 U/L或>51 U/L）（分别为趋势P = 0.032、趋势P = 0.019和趋势P = 0.009）。令人惊讶的是，对于ND 2 - 237 Leu男性，吸烟显著降低了血清ALT水平升高的风险（>30 U/L或≥25 U/L）（趋势P = 0.026和趋势P = 0.003）。吸烟似乎增加了ND 2 - 237 Met基因型男性血清ALT或血清GGT水平升高的风险，但降低了ND 2 - 237 Leu基因型男性血清ALT水平升高的风险。
NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism reportedly influences the effects of cigarette smoking on respiratory function, risk of dyslipidemia, serum non-high-density lipoprotein cholesterol levels, hematological parameters and intraocular pressure. The objective of this study was to investigate whether ND2-237 Leu/Met polymorphism modifies the effects of cigarette smoking on serum liver enzyme levels in male Japanese health check-up examinees. A total of 421 male subjects (mean age ± SD, 54.1 ± 7.7 years) were selected from among individuals visiting the hospital for regular medical check-ups. After ND2-237 Leu/Met genotyping, a cross-sectional study assessing the combined effects of ND2-237 Leu/Met polymorphism and cigarette smoking on serum aspartate aminotransferase levels, serum alanine aminotransferase (ALT) levels and serum gamma-glutamyltransferase (GGT) levels was then conducted. No statistically significant differences in serum liver enzyme levels among the three smoking status groups (never- or ex-smokers, 1–20 cigarettes smoked per day and >20 cigarettes smoked per day) by ND2-237 Leu/Met genotype were observed. However, for men with ND2-237Met, cigarette smoking significantly increased the risk of elevated levels of serum ALT (>30 U/L) or serum GGT (≥60 U/L or >51 U/L) (P for trend = 0.031, P for trend = 0.007 and P for trend = 0.004, respectively). After adjustment for age, body mass index, alcohol consumption, coffee consumption, antihypertensive treatment and antidiabetic treatment, a significant association between cigarette smoking and risk of elevated levels of serum ALT (>30 U/L) or serum GGT (≥60 U/L or >51 U/L) was also observed (P for trend = 0.032, P for trend = 0.019 and P for trend = 0.009, respectively). Surprisingly, for men with ND2-237Leu, cigarette smoking significantly decreased the risk of elevated levels of serum ALT (>30 U/L or ≥25 U/L) (P for trend = 0.026 and P for trend = 0.003, respectively). Cigarette smoking appears to increase the risk of elevated levels of serum ALT or serum GGT in ND2-237Met genotypic men, but to decrease the risk of elevated levels of serum ALT in ND2-237Leu genotypic men.
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DOI：
10.1016/j.jceh.2012.10.004
发表时间：
2013-03-01
影响因子：
3
作者：
Loomba R;Doycheva I;Bettencourt R;Cohen B;Wassel CL;Brenner D;Barrett-Connor E
通讯作者：
Barrett-Connor E
影响因子：
7.7
作者：
Higashikawa, A;Suwazono, Y;Nogawa, K
通讯作者：
Nogawa, K
影响因子：
4.4
作者：
Ohkubo, R;Nakagawa, M;Osame, M
通讯作者：
Osame, M
影响因子：
4.7
作者：
Imaizumi, Takeshi;Higaki, Yasuki;Tanaka, Keitaro
通讯作者：
Tanaka, Keitaro
影响因子：
3.3
作者：
Mukae, S;Aoki, S;Katagiri, T
通讯作者：
Katagiri, T