High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission.
High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission.
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DOI：
10.1080/22221751.2021.1903343
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发表时间：
2021-12
影响因子：
13.2
通讯作者：
Richt JA
中科院分区：
文献类型：
--
作者：
Morozov I;Monath TP;Meekins DA;Trujillo JD;Sunwoo SY;Urbaniak K;Kim IJ;Narayanan SK;Indran SV;Ma W;Wilson WC;O'Connor C;Dubey S;Troth SP;Coller BA;Nichols R;Martin BK;Feldmann H;Richt JA
最近埃博拉病毒病（EVD）对非洲公共卫生的影响清楚地表明，需要一种安全有效的疫苗来控制疫情并减轻其对全球健康的威胁。ERVEBO®是一种有效的重组水泡性口炎病毒（VSV）载体埃博拉病毒疫苗（VSV-EBOV），于2019年底获得FDA和EMA批准用于预防EVD。由于用于构建VSV-EBOV的亲本病毒VSV对牲畜具有致病性，并且疫苗病毒可由接种疫苗的人以低水平排出，因此疫苗的广泛部署需要研究其在VSV易感牲畜物种中的感染性和传播性。因此，我们在猪中对VSV-EBOV疫苗病毒进行了全面的临床分析，以确定其传染性和传播潜力。高剂量的VSV-EBOV在猪中导致VSV样临床体征，其中一部分猪在鼻注射部位和足部出现溃疡性水泡病变。与VSV-EBOV接种猪混合的未接种接触对照猪未发生感染或显示任何疾病临床体征，表明疫苗在长期密切接触期间不易传播给未接种猪。相比之下，强毒野生型VSV印第安纳州的潜伏期较短，并传播给接触对照猪。这些结果表明，当以高剂量施用时，VSV-EBOV疫苗在猪中引起水泡性疾病。此外，该研究表明VSV-EBOV疫苗不容易传播给未感染的猪，鼓励其作为有效的人类疫苗安全使用。
The recent impact of Ebola virus disease (EVD) on public health in Africa clearly demonstrates the need for a safe and efficacious vaccine to control outbreaks and mitigate its threat to global health. ERVEBO® is an effective recombinant Vesicular Stomatitis Virus (VSV)-vectored Ebola virus vaccine (VSV-EBOV) that was approved by the FDA and EMA in late 2019 for use in prevention of EVD. Since the parental virus VSV, which was used to construct VSV-EBOV, is pathogenic for livestock and the vaccine virus may be shed at low levels by vaccinated humans, widespread deployment of the vaccine requires investigation into its infectivity and transmissibility in VSV-susceptible livestock species. We therefore performed a comprehensive clinical analysis of the VSV-EBOV vaccine virus in swine to determine its infectivity and potential for transmission. A high dose of VSV-EBOV resulted in VSV-like clinical signs in swine, with a proportion of pigs developing ulcerative vesicular lesions at the nasal injection site and feet. Uninoculated contact control pigs co-mingled with VSV-EBOV-inoculated pigs did not become infected or display any clinical signs of disease, indicating the vaccine is not readily transmissible to naïve pigs during prolonged close contact. In contrast, virulent wild-type VSV Indiana had a shorter incubation period and was transmitted to contact control pigs. These results indicate that the VSV-EBOV vaccine causes vesicular illness in swine when administered at a high dose. Moreover, the study demonstrates the VSV-EBOV vaccine is not readily transmitted to uninfected pigs, encouraging its safe use as an effective human vaccine.
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影响因子：
5.5
作者：
Clarke, David K.;Hendry, R. Michael;Chen, Robert T.
通讯作者：
Chen, Robert T.
影响因子：
56.3
作者：
Heppner, D. Gray, Jr.;Kemp, Tracy L.;Monath, Thomas P.
通讯作者：
Monath, Thomas P.
影响因子：
5
作者：
Hastie, Eric;Cataldi, Marcela;Marriott, Ian;Grdzelishvili, Valery Z.
通讯作者：
Grdzelishvili, Valery Z.
影响因子：
15.8
作者：
Agnandji ST;Fernandes JF;Bache EB;Obiang Mba RM;Brosnahan JS;Kabwende L;Pitzinger P;Staarink P;Massinga-Loembe M;Krähling V;Biedenkopf N;Fehling SK;Strecker T;Clark DJ;Staines HM;Hooper JW;Silvera P;Moorthy V;Kieny MP;Adegnika AA;Grobusch MP;Becker S;Ramharter M;Mordmüller B;Lell B;VEBCON Consortium;Krishna S;Kremsner PG
通讯作者：
Kremsner PG
DOI：
10.1056/nejmoa1502924
发表时间：
2016-04-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Agnandji ST;Huttner A;Zinser ME;Njuguna P;Dahlke C;Fernandes JF;Yerly S;Dayer JA;Kraehling V;Kasonta R;Adegnika AA;Altfeld M;Auderset F;Bache EB;Biedenkopf N;Borregaard S;Brosnahan JS;Burrow R;Combescure C;Desmeules J;Eickmann M;Fehling SK;Finckh A;Goncalves AR;Grobusch MP;Hooper J;Jambrecina A;Kabwende AL;Kaya G;Kimani D;Lell B;Lemaître B;Lohse AW;Massinga-Loembe M;Matthey A;Mordmüller B;Nolting A;Ogwang C;Ramharter M;Schmidt-Chanasit J;Schmiedel S;Silvera P;Stahl FR;Staines HM;Strecker T;Stubbe HC;Tsofa B;Zaki S;Fast P;Moorthy V;Kaiser L;Krishna S;Becker S;Kieny MP;Bejon P;Kremsner PG;Addo MM;Siegrist CA
通讯作者：
Siegrist CA