Human skin commensals augment Staphylococcus aureus pathogenesis.
Human skin commensals augment Staphylococcus aureus pathogenesis.
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DOI：
10.1038/s41564-018-0198-3
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发表时间：
2018-08
影响因子：
28.3
通讯作者：
Foster SJ
中科院分区：
文献类型：
--
作者：
Boldock E;Surewaard BGJ;Shamarina D;Na M;Fei Y;Ali A;Williams A;Pollitt EJG;Szkuta P;Morris P;Prajsnar TK;McCoy KD;Jin T;Dockrell DH;van Strijp JAG;Kubes P;Renshaw SA;Foster SJ
所有细菌感染都发生在多微生物环境中，病原体群体从该环境中出现以在宿主内建立疾病。重点放在通过竞争性微生物菌群作为益生菌来防止病原体占优势。在这里，我们表明，人类病原体，金黄色葡萄球菌的毒力是由本地，多微生物，皮肤植物群和个别物种作为“促感染剂”增强。结果是病原体增殖，但不扩散。致病增强可通过颗粒细胞壁肽聚糖（PGN）介导，减少S。金黄色葡萄球菌的感染剂量超过1000倍。这种现象发生在使用S的范围内。金黄色葡萄球菌菌株、感染模型，并且不通过已建立的受体介导的途径（包括Nod1、Nod2、Myd 88和NLPR 3炎性体）介导。在小鼠败血症期间，增强依赖于肝脏驻留巨噬细胞（枯否细胞，KC），其捕获并内化病原体和“促感染剂”，导致活性氧的产生减少、病原体存活和随后的多发性肝脓肿形成。增强的感染模型更接近于自然情况，并建立了居民环境微生物群落在入侵病原体引发疾病中的作用。由于人体内微生物菌群普遍存在，它在增加感染易感性中的作用. aureus强调了预防疾病的潜在策略。
All bacterial infections occur within a polymicrobial environment, from which a pathogen population emerges to establish disease within a host. Emphasis has been placed on prevention of pathogen dominance by competing microflora acting as probiotics. Here we show that virulence of the human pathogen, Staphylococcus aureus is augmented by native, polymicrobial, commensal skin flora and individual species acting as “proinfectious agents”. The outcome is pathogen proliferation but not commensal. Pathogenesis augmentation can be mediated by particulate cell wall peptidoglycan (PGN), reducing the S. aureus infectious dose by over 1000-fold. This phenomenon occurs using a range of S. aureus strains, infection models and is not mediated by established receptor-mediated pathways including Nod1, Nod2, Myd88 and the NLPR3 inflammasome. During mouse sepsis, augmentation depends on liver resident macrophages (Kupffer cells, KC), that capture and internalise both pathogen and ‘proinfectious agent’, leading to reduced production of reactive oxygen species, pathogen survival and subsequent multiple liver abscess formation. The augmented infection model more closely resembles the natural situation and establishes the role of resident environmental microflora in initiation of disease by an invading pathogen. As human microflora is ubiquitous its role in increasing susceptibility to infection S. aureus highlights potential strategies for disease prevention.
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影响因子：
3.1
作者：
Gauguet, Stefanie;D'Ortona, Samantha;Pier, Gerald B.
通讯作者：
Pier, Gerald B.
DOI：
10.1099/00221287-6-1-2-95
发表时间：
1952-01-01
期刊：
JOURNAL OF GENERAL MICROBIOLOGY
影响因子：
--
作者：
DUTHIE, ES;LORENZ, LL
通讯作者：
LORENZ, LL
DOI：
10.1099/00221287-144-4-1005
发表时间：
1998-04-01
期刊：
MICROBIOLOGY-UK
影响因子：
--
作者：
Modun, BJ;Cockayne, A;Williams, P
通讯作者：
Williams, P
影响因子：
6.4
作者：
Fey PD;Endres JL;Yajjala VK;Widhelm TJ;Boissy RJ;Bose JL;Bayles KW
通讯作者：
Bayles KW
影响因子：
4.8
作者：
Cheng, Alice G.;Kim, Hwan Keun;Missiakas, Dominique M.
通讯作者：
Missiakas, Dominique M.