Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion.
Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion.
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DOI：
10.1039/d2sc02074b
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发表时间：
2022-06-15
期刊：
影响因子：
8.4
通讯作者：
中科院分区：
文献类型：
--
作者：
以含顺式二醇基团的水溶性甲基丙烯酸前驱体为原料，采用可逆加成-破碎链转移（RAFT）水分散聚合法制备了一系列热响应型二嵌段共聚物蠕虫凝胶。使用高碘酸钠水溶液选择性氧化可得到相应的醛功能蠕虫凝胶。醛基位于空间稳定剂链内，醛的含量可以通过改变高碘酸盐/顺式二醇的摩尔比来调节。这些醛功能蠕虫凝胶在其黏附性能方面的评估与荧光显微镜为基础的分析援助。使用猪膀胱粘膜作为模型底物，我们证明这些蠕虫凝胶提供了与壳聚糖相当程度的粘膜粘附，壳聚糖被广泛认为是这种情况下的“金标准”阳性对照。最佳的醛功能化程度约为30%：较低的功能化程度导致较弱的黏附，而较高的功能化程度则损害了这些蠕虫凝胶的理想热响应行为。通过高酸盐氧化优化热响应性二嵌段共聚物蠕虫凝胶的醛含量，使其在猪粘膜荧光试验中的黏附性能与壳聚糖（金标准阳性对照）相当。
A series of thermoresponsive diblock copolymer worm gels is prepared via reversible addition–fragmentation chain transfer (RAFT) aqueous dispersion polymerization of 2-hydroxypropyl methacrylate using a water-soluble methacrylic precursor bearing pendent cis-diol groups. Selective oxidation using an aqueous solution of sodium periodate affords the corresponding aldehyde-functional worm gels. The aldehyde groups are located within the steric stabilizer chains and the aldehyde content can be adjusted by varying the periodate/cis-diol molar ratio. These aldehyde-functional worm gels are evaluated in terms of their mucoadhesion performance with the aid of a fluorescence microscopy-based assay. Using porcine urinary bladder mucosa as a model substrate, we demonstrate that these worm gels offer a comparable degree of mucoadhesion to that afforded by chitosan, which is widely regarded to be a ‘gold standard’ positive control in this context. The optimum degree of aldehyde functionality is approximately 30%: lower degrees of functionalization lead to weaker mucoadhesion, whereas higher values compromise the desirable thermoresponsive behavior of these worm gels. Optimizing the aldehyde content of thermoresponsive diblock copolymer worm gels via periodate oxidation leads to mucoadhesion performance comparable to that of chitosan (a gold standard positive control) in a fluorescence assay using porcine mucosa.
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影响因子：
16.6
作者：
Hu S;Pei X;Duan L;Zhu Z;Liu Y;Chen J;Chen T;Ji P;Wan Q;Wang J
通讯作者：
Wang J
影响因子：
18.2
作者：
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通讯作者：
Armes SP
DOI：
10.1039/f29767201525
发表时间：
1976-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS II
影响因子：
--
作者：
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通讯作者：
NINHAM, BW
DOI：
10.1002/anie.202015298
发表时间：
2021-05-17
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Brotherton EE;Jesson CP;Warren NJ;Smallridge MJ;Armes SP
通讯作者：
Armes SP
影响因子：
5.5
作者：
Ferguson, CJ;Hughes, RJ;Such, CH
通讯作者：
Such, CH