Collagenolytic activity in crevicular fluid from patients with chronic adult periodontitis, localized juvenile periodontitis and gingivitis, and from healthy control subjects.
Collagenolytic activity in crevicular fluid from patients with chronic adult periodontitis, localized juvenile periodontitis and gingivitis, and from healthy control subjects.
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慢性成人牙周炎、局部青少年牙周炎和牙龈炎患者以及健康对照受试者的沟液中的胶原蛋白溶解活性。
DOI：
10.1111/j.1600-0765.1987.tb01603.x
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发表时间：
1987
影响因子：
3.5
通讯作者：
H. Birkedal‐Hansen
中科院分区：
文献类型：
--
作者：
Benardo Villela;R. Cogen;A. Bartolucci;H. Birkedal‐Hansen
从25名健康对照者、25名牙龈炎、25名慢性成人牙周炎（CAP）和8名LJP患者中取样的龈沟液（GCF）中的胶原溶解活性与临床疾病参数相关，使用部位和患者作为取样单位。在患者中，胶原酶活性随着疾病的严重程度而增加，其顺序为：健康<牙龈炎<牙周炎。在不同部位中，CAP和LJP的龈沟液胶原酶活性与牙周袋深度显著相关，而牙龈炎患者的胶原酶活性与牙周袋深度无关。酶活性也与GI评分在LJP，但没有在CAP和牙龈炎患者。在健康、牙龈炎和CAP组各10名患者的亚组中，检查了酶活性和龈沟液体积（流量）的相关性。在CAP患者中，液体体积与袋深度之间存在显著相关性，在牙龈炎患者中，液体体积与GI评分之间存在显著相关性，但胶原酶活性与液体体积之间没有观察到相关性。胶原溶解酶被证明是一种真正的脊椎动物胶原酶，来源于未经鉴定的宿主细胞。CAP患者龈沟液中酶浓度为10 μg/ml。
Collagenolytic activity in gingival crevicular fluid (GCF) sampled from 25 healthy control subjects, 25 gingivitis, 25 chronic adult periodontitis (CAP) and 8 LJP patients was correlated with clinical disease parameters using both the site and the patient as sampling units. Among patients collagenase activity increased with the severity of the disease in the order: healthy < gingivitis < periodontitis. Among sites, significant correlation was found between GCF collagenase activity and pocket depth in CAP and LJP, but not in gingivitis patients. Enzyme activity was also correlated with GI score in LJP, but not in CAP and gingivitis patients. In a subset of 10 patients in each of the healthy, gingivitis and CAP groups the association of enzyme activity and crevicular fluid volume (flow) was examined. Significant correlation was found between fluid volume and pocket depth in CAP patients, and between fluid volume and GI score in gingivitis patients, but no association was observed between collagenase activity and fluid volume. The Collagenolytic enzyme was shown to be a genuine vertebrate collagenase derived from unidentified host cells. The concentration of the enzyme in crevicuar fluid from CAP patients was in the order of 10 μg/ml.
人皮肤成纤维细胞前胶原酶：有机汞和胰蛋白酶的激活机制。
影响因子：
2.9
作者：
Stricklin,GP;Jeffrey,JJ;Roswit,WT;Eisen,AZ
通讯作者：
Eisen,AZ
影响因子：
6.7
作者：
Haffajee,AD;Socransky,SS;Goodson,JM;Lindhe,J
通讯作者：
Lindhe,J