Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin.

Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin.
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人皮肤成纤维细胞前胶原酶:有机汞和胰蛋白酶的激活机制。

DOI:
10.1021/bi00270a009
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发表时间:
1983
期刊:
影响因子:
2.9
通讯作者:
Eisen,AZ
Eisen,AZ
中科院分区:
生物学3区
文献类型:
--
作者:
Stricklin,GP;Jeffrey,JJ;Roswit,WT;Eisen,AZ

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乔治P斯特里克林,“约翰J杰弗里,威廉T。Roswit和亚瑟Z.论文摘要:本研究以人皮肤成纤维细胞胶原原酶为模型系统,研究了有机汞和胰蛋白酶的激活途径。对羟基苯甲酸汞、对氨基苯汞和对氨基苯汞乙酸三种有机汞能完全激活人皮肤胶原原酶而不伴随分子量的损失。随后产生了较低分子量的物质,特别是第四种有机汞,氯化苯汞。活化过程依赖于有机物的浓度,
George P. Stricklin,’" John J. Jeffrey, William T. Roswit, and Arthur Z. Eisen abstract: Pure human skin fibroblast procollagenase has been utilized in this study as a model system in which to examine the pathways of organomercurial and trypsin acti-vation. Three organomercurials, p-(hydroxymercuri) benzoate, mersalyl, and p-aminophenylmercuric acetate, were able to fully activate human skin procollagenase with no accompa-nying loss of molecular weight. Lower molecular weight species were subsequently produced, particularly with a fourth organomercurial, phenylmercuric chloride. The activation process was dependent upon the concentration of the orga-
DOI: 10.1021/bi00874a007
发表时间: 1966
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影响因子: 2.9
作者:
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DOI: 10.1016/0003-9861(81)90530-0
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