Chronic social defeat stress in female mice leads to sex-specific behavioral and neuroendocrine effects
Chronic social defeat stress in female mice leads to sex-specific behavioral and neuroendocrine effects
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雌性小鼠的慢性社交失败压力会导致性别特异性行为和神经内分泌效应
DOI：
10.1080/10253890.2020.1864319
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发表时间：
2021
期刊：
影响因子：
2.3
通讯作者：
Schmidt MV
中科院分区：
文献类型：
--
作者：
van Doeselaar L;Yang H;Bordes J;Brix L;Engelhardt C;Tang F;Schmidt MV
多年来，人们越来越清楚地看到，男性和女性对环境压力的反应不同，这突出了在研究压力的影响时将两性都包括在内的重要性。本研究旨在进一步了解将雌性小鼠暴露于21天的慢性社会失败压力（CSDS）的详细后果。我们使用了一种依赖于雄性尿液中气味和信息素的能力来触发雄性小鼠攻击行为的协议。将收集的雄性C57 B1/6 n尿液应用于雌性C57 B1/6 n小鼠，然后根据CDSD方案每天用新的雄性CD 1小鼠攻击。对照组雌性动物每天成对饲养并处理。在实验过程中，生理，神经内分泌和行为的变化进行了评估。CSDS暴露导致许多生理变化，如体重增加、肾上腺增大和胸腺重量减少、放大HPA轴负反馈和增加焦虑样行为。然而，没有观察到广泛的社交回避行为。本研究为进一步了解雌性小鼠对CSDS的生理、神经内分泌和行为反应提供了重要信息，这些反应部分依赖于动情周期阶段。该协议将允许直接比较的男性和女性的反应CSDS，并使性别特异性研究的机制，个人的压力resilience.Lay summaryIn这项研究中，我们发现，有差异的方式，女性和男性小鼠对慢性社会应激条件下，当谈到行为和激素的变化。
Over the years, it has become increasingly clear that males and females respond differently towards environmental stressors, highlighting the importance of including both sexes when studying the effects of stress. This study aims to provide further insight into the detailed consequences of exposing female mice to 21 days of chronic social defeat stress (CSDS). We used a protocol that relies on the ability of odorants and pheromones in male urine to trigger male mouse aggressive behavior. Collected male C57Bl/6n urine was applied to female C57Bl/6n mice who were then attacked by a novel male CD1 mouse each day according to the CDSD protocol. Control females were pair-housed and handled daily. Physiological, neuroendocrine and behavioral changes were evaluated during the experiment. CSDS exposure resulted in number of physiological changes, such as body weight gain, enlarged adrenals and reduced thymus weight, exaggerated HPA-axis negative feedback and increased anxiety-like behavior. However, no generalized social avoidance behavior was observed. This study provides important insights in the physiological, neuroendocrine and behavioral responses of female mice to CSDS, which are partially dependent on estrous cycle stage. This protocol will allow direct comparison of male and female responses to CSDS and enable sex-specific study of mechanisms underlying individual stress resilience.Lay summaryIn this study we found that there are differences in the way that female and male mice respond towards chronic social stress conditions when it comes to behavior and hormonal changes.
卵巢激素对成年雌性大鼠应激诱导的激素反应、糖皮质激素受体表达和易位以及受体信号相关基因的影响
影响因子：
2.3
作者：
Matthew R. Green;M. Marcolin;C. McCormick
通讯作者：
C. McCormick