In Vitro Modeling of Mechanics in Cancer Metastasis.
In Vitro Modeling of Mechanics in Cancer Metastasis.
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DOI：
10.1021/acsbiomaterials.7b00041
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发表时间：
2018-02-12
影响因子：
5.8
通讯作者：
Moeendarbary E
中科院分区：
文献类型：
--
作者：
Malandrino A;Kamm RD;Moeendarbary E
除了大量的遗传和生化改变外，细胞及其细胞外环境的异常形态、结构和机械变化是肿瘤侵袭和转移的关键特征。此外，现在很明显，机械信号和生化信号一起参与了癌症发生、进展和扩散的关键步骤。尽管它很重要，但在临床甚至动物模型中研究转移的不同步骤的机制是非常具有挑战性的。虽然在开发用于研究癌症遗传和生物学方面的先进体外模型方面取得了相当大的进展，但对能够真实地捕获生物和机械因素的模型的关注较少。这主要是由于缺乏适当的模型和测量工具。在介绍了力学在癌症转移中的核心作用之后，我们展望了新型体外试验的出现及其与先进测量技术的结合，以在更相关的转移疾病条件下探测和概括力学。
In addition to a multitude of genetic and biochemical alterations, abnormal morphological, structural, and mechanical changes in cells and their extracellular environment are key features of tumor invasion and metastasis. Furthermore, it is now evident that mechanical cues alongside biochemical signals contribute to critical steps of cancer initiation, progression, and spread. Despite its importance, it is very challenging to study mechanics of different steps of metastasis in the clinic or even in animal models. While considerable progress has been made in developing advanced in vitro models for studying genetic and biological aspects of cancer, less attention has been paid to models that can capture both biological and mechanical factors realistically. This is mainly due to lack of appropriate models and measurement tools. After introducing the central role of mechanics in cancer metastasis, we provide an outlook on the emergence of novel in vitro assays and their combination with advanced measurement technologies to probe and recapitulate mechanics in conditions more relevant to the metastatic disease.
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DOI：
10.1016/j.mattod.2015.05.002
发表时间：
2015-12
期刊：
Materials today (Kidlington, England)
影响因子：
--
作者：
Asghar W;El Assal R;Shafiee H;Pitteri S;Paulmurugan R;Demirci U
通讯作者：
Demirci U
DOI：
10.1038/nrm3112
发表时间：
2011-05
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.2
作者：
Carey, Shawn P.;D'Alfonso, Timothy M.;Shin, Sandra J.;Reinhart-King, Cynthia A.
通讯作者：
Reinhart-King, Cynthia A.
影响因子：
3
作者：
Buchanan, Cara F.;Voigt, Elizabeth E.;Rylander, Marissa Nichole
通讯作者：
Rylander, Marissa Nichole
细胞介导的纤维募集驱动工程原纤维微环境中的细胞外基质机械感应。
影响因子：
41.2
作者：
Baker BM;Trappmann B;Wang WY;Sakar MS;Kim IL;Shenoy VB;Burdick JA;Chen CS
通讯作者：
Chen CS