Sex and Race Differences in Pain Sensitization among Patients with Chronic Low Back Pain.
Sex and Race Differences in Pain Sensitization among Patients with Chronic Low Back Pain.
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DOI：
10.1016/j.jpain.2018.07.001
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Edwards RR
中科院分区：
文献类型：
--
作者：
Meints SM;Wang V;Edwards RR
越来越多的证据表明，慢性腰痛（CLBP）与疼痛致敏有关，并且存在性别和种族差异。鉴于疼痛致敏的性别和种族差异，这被假设为CLBP中性别和种族差异的一种机制。本研究考察了CLBP患者疼痛致敏的性别和种族差异，以及灾难化作为这些差异的潜在中介的作用。我们发现，与男性相比，女性产生深层肌肉疼痛所需的压力更小，并且认为机械点状疼痛更痛苦。与非西班牙裔白人（NHW）患者相比，黑人患者对深度肌肉痛觉过敏和机械点状疼痛表现出更大的疼痛敏感性。此外，灾难化部分地介导了深层肌肉疼痛的种族差异，因此黑人参与者赞同更大的疼痛灾难化，这部分解释了他们对深层肌肉疼痛的敏感性和时间总和的增加。综上所述，这些结果支持有必要进一步研究在性别和种族差异背景下，灾难化和疼痛敏感化在CLBP经历中的作用。本研究确定了CLBP患者疼痛致敏的性别和种族差异。此外，它认识到灾难化是造成这种种族差异的一个因素。需要更多的研究来进一步剖析这些复杂的关系。
Growing evidence suggests that chronic low back pain (CLBP) is associated with pain sensitization, and that there are sex and race disparities in CLBP. Given the sex and race differences in pain sensitization, this has been hypothesized as a mechanism contributing to the sex and race disparities in CLBP. This study examined sex and race differences in pain sensitization among patients with CLBP as well as the role of catastrophizing as a potential mediator of those differences. We found that compared to males, females required less pressure to produce deep muscle pain and rated mechanical punctate pain as more painful. Compared to non-Hispanic White (NHW) patients, Black patients demonstrated greater pain sensitivity for measures of deep muscle hyperalgesia and mechanical punctate pain. Furthermore, catastrophizing partially mediated the race differences in deep muscle pain such that Black participants endorsed greater pain catastrophizing, which partially accounted for their increased sensitivity to, and temporal summation of, deep muscle pain. Taken together, these results support the need to further examine the role of catastrophizing and pain sensitization in the context of sex and race disparities in the experience of CLBP. This study identifies sex and race differences in pain sensitization among patients with CLBP. Further, it recognizes the role of catastrophizing as a contributor to such race differences. More research is needed to further dissect these complex relationships.
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影响因子：
7.4
作者：
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