Crystal structure of a group II intron in the pre-catalytic state.

Crystal structure of a group II intron in the pre-catalytic state.
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DOI:
10.1038/nsmb.2270
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发表时间:
2012-04-08
影响因子:
16.8
通讯作者:
Toor, Navtej
Toor, Navtej
中科院分区:
生物学1区
文献类型:
--
作者:
Chan, Russell T.;Robart, Aaron R.;Rajashankar, Kanagalaghatta R.;Pyle, Anna Marie;Toor, Navtej

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Group II introns are self-splicing catalytic RNAs that are thought to be ancestral to the spliceosome. Here we report the 3.65 Å crystal structure of the group II intron from Oceanobacillus iheyensis in the pre-catalytic state. The structure reveals the conformation of the 5′ splice site in the catalytic core and represents the first structure of an intron prior to the first step of splicing.
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