Positional variations in mammary gland development and cancer.
Positional variations in mammary gland development and cancer.
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DOI：
10.1007/s10911-013-9287-3
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发表时间：
2013-06
影响因子：
2.5
通讯作者：
Sterneck, Esta
中科院分区：
文献类型：
--
作者：
Veltmaat, Jacqueline M.;Ramsdell, Ann F.;Sterneck, Esta
大多数哺乳动物的乳腺是成对发育的，其中两个乳腺对称地从腹中线移开。基于这种对称性和与产奶器官相同的功能结果，很容易推定乳腺只是彼此的副本。基于我们对已发表的数据的分析，并纳入了与小鼠乳腺发育和病理学相关的新结果，我们认为这一假设是不正确的：在配对之间和配对内，乳腺彼此不同，肿瘤发病率和生物学也取决于沿前后和左右轴线的位置。这一洞察力对小鼠模型的实验设计以及物种内和物种间乳腺之间的数据外推具有重要意义。我们认为，改进对特定部位乳腺特征的记录将导致对小鼠和人类乳腺发育和癌症生物学的分子机制有更多的了解。
Most mammals develop their mammary glands in pairs of which the two counterparts are symmetrically displaced away from the ventral midline. Based on this symmetry and the same functional outcome as a milk-producing organ, the mammary glands are easily presumed to be mere copies of one another. Based on our analysis of published data with inclusion of new results related to mammary development and pathology in mice, we argue that this presumption is incorrect: Between and within pairs, mammary glands differ from one another, and tumor incidence and biology depend on the position along the anterior-posterior and the left-right axis as well. This insight has implications for experimental designs with mouse models and for data extrapolation between mammary glands within and between species. We suggest that improved documentation of location-specific mammary gland features will lead to more insights into the molecular mechanisms of mammary gland development and cancer biology in both mice and humans.
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影响因子：
2.1
作者：
DELAHUNT, B;BETHWAITE, P;NACEY, JN
通讯作者：
NACEY, JN
Pygo2 通过促进组蛋白 H3 K4 甲基化来扩增乳腺祖细胞
DOI：
10.1083/jcb.200810133
发表时间：
2009-06-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gu B;Sun P;Yuan Y;Moraes RC;Li A;Teng A;Agrawal A;Rhéaume C;Bilanchone V;Veltmaat JM;Takemaru K;Millar S;Lee EY;Lewis MT;Li B;Dai X
通讯作者：
Dai X
影响因子：
21.3
作者：
Asselin-Labat, Marie-Liesse;Sutherland, Kate D.;Visvader, Jane E.
通讯作者：
Visvader, Jane E.
影响因子：
2.7
作者：
Boras-Granic, Kata;Chang, Hong;Hamel, Paul A.
通讯作者：
Hamel, Paul A.
影响因子：
4.6
作者：
Ahn, Youngwook;Sims, Carrie;Krumlauf, Robb
通讯作者：
Krumlauf, Robb