CranialCloud: a cloud-based architecture to support trans-institutional collaborative efforts in neurodegenerative disorders.
CranialCloud: a cloud-based architecture to support trans-institutional collaborative efforts in neurodegenerative disorders.
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DOI：
10.1007/s11548-015-1189-y
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发表时间：
2015-06
影响因子：
3
通讯作者：
Dawant, Benoit M.
中科院分区：
文献类型：
--
作者：
D'Haese, Pierre-Francois;Konrad, Peter E.;Pallavaram, Srivatsan;Li, Rui;Prassad, Priyanka;Rodriguez, William;Dawant, Benoit M.
神经系统疾病对数百万人及其家庭产生毁灭性影响。这些疾病将继续构成本世纪的重要研究焦点。寻找有效的治疗和治愈方法需要多个临床神经科学、神经放射学、工程和工业专家团队。因此，需要准确和精确地传达大量信息，这一专业比以往任何时候都更有必要。在本文中，我们提出了一个支持这一愿景的分布式系统，我们称之为CranialVault云（CranialCloud）。它由一个节点网络组成，每个节点都有存储和处理数据的能力，共享相同的空间标准化过程，从而保证共同的参考空间。我们详细说明并证明设计选择，各个节点的架构和功能，这些节点的交互方式，以及如何分布式系统可以用来支持跨机构的研究。我们讨论了收集1,600多名患者数据的系统的当前状态，以及我们如何设想它的发展。我们认为，寻找和开发有希望的治疗方法和治愈方法的最快方法是允许研究人员团队聚合数据，在空间上规范化这些数据，并共享它们。Cranialvault系统是支持这一愿景的系统。
Neurological diseases have a devastating impact on millions of individuals and their families. These diseases will continue to constitute a significant research focus for this century. The search for effective treatments and cures requires multiple teams of experts in clinical neurosciences, neuroradiology, engineering and industry. Hence, the need to communicate a large amount of information with accuracy and precision is more necessary than ever for this specialty. In this paper, we present a distributed system that supports this vision, which we call the CranialVault Cloud (CranialCloud). It consists in a network of nodes, each with the capability to store and process data, that share the same spatial normalization processes, thus guaranteeing a common reference space. We detail and justify design choices, the architecture and functionality of individual nodes, the way these nodes interact, and how the distributed system can be used to support inter-institutional research. We discuss the current state of the system that gathers data for more than 1,600 patients and how we envision it to grow. We contend that the fastest way to find and develop promising treatments and cures is to permit teams of researchers to aggregate data, spatially normalize these data, and share them. The Cranialvault system is a system that supports this vision.
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影响因子：
3
作者：
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通讯作者：
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影响因子：
10.9
作者：
D'Haese, Pierre-Francois;Pallavaram, Srivatsan;Li, Rui;Remple, Michael S.;Kao, Chris;Neimat, Joseph S.;Konrad, Peter E.;Dawant, Benoit M.
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作者：
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通讯作者：
Calhoun VD