Alterations in contractile properties of human skeletal muscle induced by joint immobilization
Alterations in contractile properties of human skeletal muscle induced by joint immobilization
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关节固定引起的人体骨骼肌收缩特性的改变
DOI：
10.1111/j.1469-7793.2001.0521k.x
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
M. Narusawa
中科院分区：
文献类型：
--
作者：
K. Seki;Yuko Taniguchi;M. Narusawa
1以人第一骨间背侧肌（FDI）为材料，研究关节制动对骨骼肌收缩特性的影响。2将中指、食指和拇指制动6周，分别在制动前、制动3周和6周后以及6周恢复期后测试手指前屈肌的收缩性能。3通过经皮电刺激诱发FDI的抽搐和强直收缩。从抽搐收缩测量峰值抽搐张力（Pt）、收缩时间（CT）和半松弛时间（1/2 RT），而从使用各种频率（10 - 100 Hz）刺激诱发的强直收缩（2 s）获得刺激频率-力关系。使用Burke疲劳方案测试FDI的疲劳性。4制动6周后Pt明显升高（P < 0.05），CT和1/2 RT变化不大。在整个固定期间，FDI疲劳指数没有变化。5刺激频率-力的关系通过固定向左移动，表明较低的刺激速率诱发了较大比例的最大力。制动后10 Hz刺激诱发的强直力增强（P < 0.05）。而50 Hz以上频率诱发的力（包括最大强直张力）降低（P < 0.05）。结果表明，制动后大鼠的抽搐/强直比明显增加（P < 0.01）。6制动引起的FDI抽动/强直比率的变化与FDI运动神经元估计的最大放电频率呈显著相关（r= 0.80，P < 0.05）。[7]这表明，关节制动后FDI肌肉收缩特性的变化与FDI运动神经元放电频率调制的变化有因果关系。
1 The effects of joint immobilization on the contractile properties of human skeletal muscle were examined using the first dorsal interosseous (FDI) muscle. 2 The middle finger, index finger and thumb were immobilized for a period of 6 weeks, and the contractile properties of FDI were tested before immobilization, after 3 and 6 weeks of immobilization, and after a 6 week recovery period. 3 Twitch and tetanic contractions of FDI were evoked by per‐cutaneous electrical stimulation. The peak twitch tension (Pt), contraction time (CT) and half‐relaxation time (1/2RT) were measured from twitch contractions, while the stimulus frequency‐force relationship was obtained from the tetanic contractions (2 s) evoked using various frequencies of stimulation (10‐100 Hz). The fatigability of FDI was tested using Burke's fatigue protocol. 4 Pt was significantly increased after 6 weeks of immobilization (P < 0.05) but little alteration was observed in CT or 1/2RT. No change was noted in the FDI fatigue index throughout the immobilization period. 5 The stimulus frequency‐force relationship was shifted to the left by immobilization, indicating that a larger percentage of maximal force was evoked by the lower rates of stimulation. Indeed, the tetanic force evoked by a stimulus frequency of 10 Hz was enhanced after immobilization (P < 0.05). On the other hand, the force evoked by frequencies above 50 Hz, including maximal tetanic tension, was decreased (P < 0.05). As a result, the twitch/tetanus ratio was increased (P < 0.01) after immobilization. 6 The changes induced by immobilization in the FDI twitch/tetanus ratio and the estimated maximal firing rate of FDI motoneurones showed a significant correlation (r= 0.80, P < 0.05). 7 It is suggested that the changes in the contractile properties of the FDI muscle seen after joint immobilization are causally linked to the changes in firing rate modulation of FDI motoneurones.
部分脊髓损伤期间运动神经元突触输入的变化。
影响因子：
4.1
作者：
Heckman,CJ
通讯作者：
Heckman,CJ
影响因子：
3.3
作者：
FUGLEVAND, AJ;BILODEAU, M;ENOKA, RM
通讯作者：
ENOKA, RM