The role of the subfornical organ in angiotensin II-salt hypertension in the rat.
The role of the subfornical organ in angiotensin II-salt hypertension in the rat.
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DOI：
10.1113/expphysiol.2011.060491
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发表时间：
2012-01
影响因子：
2.7
通讯作者：
Fink GD
中科院分区：
文献类型：
--
作者：
Osborn JW;Hendel MD;Collister JP;Ariza-Guzman PA;Fink GD
在实验动物中由血管紧张素II（AngII）的慢性输注引起的高血压部分地依赖于交感神经系统的活性增加。这种慢性交感神经兴奋性反应被高盐饮食放大，表明循环AngII和饮食盐对脑中交感神经调节通路的相互作用。本研究测试的假设，穹窿下器官（SFO），一个前脑脑室周围的器官，已知被激活的循环血管紧张素II，是至关重要的高血压的发病机制诱导慢性血管紧张素II管理大鼠高盐饮食（血管紧张素II盐模型）。随机选择大鼠进行穹窿下器官损伤（SFOx）或假手术（SHAM），然后置于高盐（2%NaCl）饮食。一周后，对大鼠进行平均动脉压（MAP）和心率（HR）的无线电遥测测量，并将其置于代谢笼中以测量钠和水平衡。在5天对照期内，SFOx大鼠的基线MAP略低于（但无统计学意义）SHAM大鼠。在随后的10天AngII给药期间，SFOx大鼠的MAP在统计学上较低。然而，当通过比较从5天基线期的变化来分析对AngII的MAP反应时，仅在AngII的第5天组间MAP显著不同。在整个方案中，两组之间的水或钠平衡无差异。我们的结论是，虽然SFO是所需的AngII盐高血压在大鼠中的完整表达，其他大脑网站也参与。
Hypertension caused by chronic infusion of angiotensin II (AngII) in experimental animals is dependent, in part, on increased activity of the sympathetic nervous system. This chronic sympathoexcitatory response is amplified by a high salt diet suggesting an interaction of circulating AngII and dietary salt on sympathetic regulatory pathways in the brain. The present study tested the hypothesis that the subfornical organ (SFO), a forebrain circumventricular organ known to be activated by circulating AngII, is crucial to the pathogenesis of hypertension induced by chronic AngII administration in rats on a high salt diet (AngII-salt model). Rats were randomly selected to undergo either subfornical organ lesion (SFOx) or sham surgery (SHAM) and then placed on a high salt (2% NaCl) diet. One week later rats were instrumented for radiotelemetric measurement of mean arterial pressure (MAP) and heart rate (HR) and placed in metabolic cages to measure sodium and water balance. Baseline MAP was slightly (but not statistically) lower in SFOx compared to SHAM rats during the 5 day control period. During the subsequent 10 days of AngII administration, MAPwas statistically lower in SFOx rats. However, when MAP responses to AngII were analyzed by comparing the change from the 5 day baseline period, only on the 5th day of AngII was MAP significantly different between groups. There were no differences between groups for water or sodium balance throughout the protocol. We conclude that, although the SFO is required for the complete expression of AngII-salt hypertension in the rat, other brains sites are also involved.
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