Ex Vivo Analysis of a Porcine Bicuspid Aortic Valve and Aneurysm Disease Model.
Ex Vivo Analysis of a Porcine Bicuspid Aortic Valve and Aneurysm Disease Model.
复制标题
猪二叶式主动脉瓣和动脉瘤疾病模型的离体分析。
DOI:
10.1016/j.athoracsur.2020.05.086
复制
发表时间:
2021-03
期刊:
影响因子:
--
通讯作者:
Woo YJ
中科院分区:
文献类型:
--
作者:
Zhu Y;Imbrie-Moore AM;Park MH;Paulsen MJ;Wang H;MacArthur JW;Woo YJ
We identified an extremely rare congenital porcine type 0 lateral bicuspid aortic valve from a fresh porcine heart. Using a 3-dimensionally printed ex vivo left heart simulator, we analyzed valvular hemodynamics at baseline, in an aortic aneurysm disease model, and after valve-sparing root replacement. We showed that bicuspid aortic valve regurgitation due to aortic aneurysm can be successfully repaired without significant hemodynamic impairment using the valve-sparing root replacement technique in an individualized approach. Our results provide direct hemodynamic evidence supporting the use of valve-sparing root replacement for patients with bicuspid aortic valve regurgitation.
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