Comparative Study of Alterations in Tri-iodothyronine (T3) and Thyroxine (T4) Hormone Levels in Breast and Ovarian Cancer.
Comparative Study of Alterations in Tri-iodothyronine (T3) and Thyroxine (T4) Hormone Levels in Breast and Ovarian Cancer.
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DOI：
10.12669/pjms.306.5294
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发表时间：
2014-11
影响因子：
2.2
通讯作者：
Asif M
中科院分区：
文献类型：
--
作者：
Rasool M;Naseer MI;Zaigham K;Malik A;Riaz N;Alam R;Manan A;Sheikh IA;Asif M
目的：本研究旨在探讨乳腺癌和卵巢癌患者甲状腺激素（T3, T4）水平的变化。方法：共招募120名无甲状腺病史的受试者，分为3组；A， B和c， A组作为对照，以健康个体为对照。B组为乳腺癌患者，C组为卵巢癌患者。取5 ml血样分析血清T3（三碘甲状腺原氨酸）和T4（甲状腺素）激素水平。R结果：各组间差异有统计学意义（P=0.000*、P=0.017*）。与健康对照组相比，乳腺癌患者的T3 （P=0.000*）和T4（0.005*）水平显著升高。而在卵巢癌患者中，血清T3和T4水平的结果相互矛盾，即T3 （P=0.209）和T4 （P=0.050）与对照组相比差异不显著。我们的研究结果表明，乳腺癌和卵巢癌患者的甲状腺激素（T3和T4）水平与正常健康人相比发生了变化。结论：甲状腺功能亢进对乳腺癌和卵巢癌细胞增殖有重要影响。
Objective : The present study was designed to investigate variations in the levels of thyroid hormones (T3, T4) in breast and ovarian cancers patients. Methods : A total 120 subjects were recruited (without thyroid history) divided into three groups; A, B and C. Group A as control with healthy individuals. While group B and group C were consisting of breast cancer and ovarian cancer patient respectively. Blood samples (5 ml) were taken and analyzed to estimate the levels of serum T3 (tri-iodothyronine) and T4 (thyroxin) hormones. R esults : Statistically significant difference (P=0.000* and P=0.017*) was obtained among all groups. A significant increase in T3 (P=0.000*) and T4 (0.005*) levels was observed among breast cancer patients as compared to healthy controls. While for ovarian cancer patients conflicting results were found for T3 and T4 levels in the serum i.e. insignificant difference was found in T3 (P=0.209) and T4 (P=0.050) as compared to control. Our results showed that in the breast cancer and ovarian cancer patients the thyroid hormone (T3 and T4) level has been altered from the normal ranges as compared to the normal healthy individuals. Conclusion : We conclude that hyperthyroidism has profound effects on breast cancer and ovarian cancer cells proliferation.
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DOI：
10.1590/s0100-879x2005000500014
发表时间：
2005-05-01
影响因子：
2.3
作者：
Saraiva, P.P.;Figueiredo, N.B.;Nogueira, C.R.
通讯作者：
Nogueira, C.R.
DOI：
10.1186/bcr609
发表时间：
2003
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Turken O;NarIn Y;DemIrbas S;Onde ME;Sayan O;KandemIr EG;YaylacI M;Ozturk A
通讯作者：
Ozturk A
影响因子：
6.6
作者：
Burns, Robert;O'Herlihy, Colm;Smyth, Peter P. A.
通讯作者：
Smyth, Peter P. A.
影响因子：
5.4
作者：
Ness, RB;Grisso, JA;Schlesselman, JJ
通讯作者：
Schlesselman, JJ
影响因子：
6.2
作者：
Cristofanilli, M;Yamamura, Y;Hortobagyi, GN
通讯作者：
Hortobagyi, GN