Ursolic acid treats renal tubular epithelial cell damage induced by calcium oxalate monohydrate via inhibiting oxidative stress and inflammation.
Ursolic acid treats renal tubular epithelial cell damage induced by calcium oxalate monohydrate via inhibiting oxidative stress and inflammation.
复制标题
熊果酸通过抑制氧化应激和炎症来治疗一水草酸钙引起的肾小管上皮细胞损伤
DOI：
10.1080/21655979.2021.1955176
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发表时间：
2021-12
期刊：
影响因子：
4.9
通讯作者：
Dou Z
中科院分区：
文献类型：
--
作者：
Jia Z;Li W;Bian P;Yang L;Liu H;Pan D;Dou Z
熊果酸（UA）具有抗氧化和抗炎作用。然而，尚不清楚它是否对一水草酸钙（COM）晶体诱导的肾损伤具有保护作用。本研究旨在阐明UA对COM肾损伤保护作用的可能机制。结果表明，高、低剂量UA均能减少COM大鼠肾组织COM结晶，降低血浆尿素、肌酐和中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平，减少肾组织和HK-2细胞凋亡，抑制Bax表达，升高Bcl-2表达。此外，UA还能减轻COM大鼠肾纤维化，抑制肾脏和HK-2细胞α-SMA和I型胶原蛋白的表达，通过上调Nrf 2/HO-1通路抑制COM引起的体内外氧化损伤，通过抑制TLR 4/NF-κB通路的激活，上调SOD水平，降低MDA水平，下调TNF-α、IL-1β和IL-6水平。综上所述，本研究结果提示，通过UA可以有效改善COM所致的肾损伤，为今后临床上开发有效的肾损伤治疗药物提供了有力的数据支持。图形摘要
ABSTRACT Ursolic acid (UA) has been proved to have antioxidant and anti-inflammatory effects. However, it is not clear whether it has a protective impact on kidney damage induced by crystals of calcium oxalate monohydrate (COM). This work aimed to make clear the potential mechanism of UA protecting COM-induced kidney damage. The results manifested that high- and low-dose UA reduced COM crystals in COM rats’ kidney, down-regulated urea, creatinine, and neutrophil gelatinase-associated lipocalin (NGAL) levels in rat plasma, declined kidney tissue and HK-2 cell apoptosis, inhibited Bax expression but elevated Bcl-2 expression. Additionally, UA alleviated renal fibrosis in COM rats, repressed α-SMA and collagen I protein expressions in the kidney and COM rats’ HK-2 cells, depressed COM-induced oxidative damage in vivo and in vitro via up-regulating Nrf2/HO-1 pathway, up-regulated SOD levels and reduced MDA levels, down-regulated TNF-α, IL-1β, and IL-6 levels in vivo and in vitro via suppressing activation of TLR4/NF-κB pathway. In summary, the results of this study suggest that COM-induced renal injury can be effectively improved via UA, providing powerful data support for the development of effective clinical drugs for renal injury in the future. Graphical abstract
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DOI：
10.26355/eurrev_202006_21542
发表时间：
2020-06-01
影响因子：
3.3
作者：
Fan, Q-X;Gong, S-Q;Zhang, F-J
通讯作者：
Zhang, F-J
影响因子：
7.2
作者：
Daniyal, Muhammad;Liu, Yongbei;Yuhui, Qin
通讯作者：
Yuhui, Qin
DOI：
10.1007/s00018-016-2223-0
发表时间：
2016-09
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Loboda A;Damulewicz M;Pyza E;Jozkowicz A;Dulak J
通讯作者：
Dulak J
影响因子：
3.1
作者：
Wang, Shuo;Du, Peng;Yang, Yong
通讯作者：
Yang, Yong
腾丹胶囊通过抑制骨膜素介导的肾纤维化预防 SHR 高血压肾损伤
影响因子：
5.6
作者：
Du X;Tao Q;Du H;Zhao Z;Dong Y;He S;Shao R;Wang Y;Han W;Wang X;Zhu Y
通讯作者：
Zhu Y