Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment.
Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment.
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仿生纳米递送系统白藜芦醇在结直肠癌治疗中诱导铁死亡的抗癌作用
DOI：
10.1016/j.ajps.2022.07.006
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发表时间：
2022-08
影响因子：
10.2
通讯作者：
Li, Xiaolin
中科院分区：
文献类型：
--
作者：
Zhang, Ziting;Ji, You;Hu, Nan;Yu, Qinqi;Zhang, Xinrui;Li, Jie;Wu, Fenglei;Xu, Huae;Tang, Qiyun;Li, Xiaolin
铁凋亡是一种由铁依赖性脂质过氧化作用引起的细胞程序性死亡的新形式，它可能是一种潜在的肿瘤治疗策略。本研究首次证明了中药单体白藜芦醇（Resveratrol，RSV）通过ROS依赖的铁凋亡途径有效抑制结肠癌细胞的生长。RSV可引起大肠癌细胞活性氧和脂质过氧化反应的增加，最终导致铁凋亡。此外，RSV可通过下调通道蛋白溶质载体家族7成员11（SLC 7A 11）和谷胱甘肽过氧化物酶4（GPX 4）的表达来促进铁凋亡。为提高RSV的释放效率，将RSV-聚己内酯-聚乙二醇（PCL-PEG）纳米粒与红细胞膜复合，制备了RSV-纳米粒（RSV-NPs@RBCm）。RSV-NPs@RBCm提供了逃避巨噬细胞吞噬作用并具有长循环效应的可能性。此外，当与肿瘤穿透肽iRGD偶联时，其可以触发增强的组织穿透肿瘤特异性，RSV-NPs@RBCm向肿瘤中的递送将显著改善。来自体内研究的结果证明了对CRC的优异治疗功效。总之，我们的研究强调了RSV作为亚铁凋亡诱导抗癌剂的治疗潜力，并且当加载到仿生纳米平台中时，它可能为RSV加载的纳米系统用于结直肠癌治疗铺平道路。RSV-NPs被红细胞膜包裹，在iRGD的协同作用下，红细胞膜在肿瘤部位积累更多。白藜芦醇制剂在肿瘤部位释放，然后通过铁凋亡（最近发现的细胞死亡途径）诱导结直肠癌细胞死亡。
Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid peroxidation, which may be a potential strategy for cancer therapy. Here we demonstrated for the first time that Resveratrol (RSV), a traditional Chinese medicine (TCM) chemical monomer, could effectually inhibit the growth of colon cancer cells through the ROS-dependent ferroptosis pathway. Mechanistically, RSV evoked the increase of reactive oxygen species and lipid peroxidation in colorectal cancer cells, and eventually lead to ferroptosis. Furthermore, RSV could promote ferroptosis by downregulating the expression of the channel protein solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4). To improve the delivery efficiency of RSV, a biomimetic nanocarrier was developed by coating RSV-loaded poly(ε-caprolactone)–poly(ethylene glycol) (PCL-PEG) nanoparticles with erythrocyte membrane (RSV-NPs@RBCm). The RSV-NPs@RBCm provide the possibility to escape macrophage phagocytosis and have a long circulation effect. In addition, when coupled with a tumor-penetrating peptide iRGD, which could trigger enhanced tissue penetration tumor-specifically, the delivery of RSV-NPs@RBCm into tumors would be significantly improved results from the in vivo study demonstrated an excellent treatment efficacy for CRC. Altogether, our study highlighted the therapeutic potential of RSV as a ferroptosis-inducing anticancer agent and when loaded into a biomimetic nanoplatform, it might pave the way for the application of RSV loaded nanosystems for colorectal cancer treatment. RSV-NPs were coated with erythrocyte membranes, which accumulated more in the tumor site under the coordination of iRGD. Resveratrol formulations were released at the tumor site and then induced colorectal cancer cell death through the ferroptosis, a most recently discovered cell death pathway.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
葫芦素 B 诱导人鼻咽癌细胞铁死亡的分子机制和治疗潜力
影响因子：
9
作者：
Huang S;Cao B;Zhang J;Feng Y;Wang L;Chen X;Su H;Liao S;Liu J;Yan J;Liang B
通讯作者：
Liang B
影响因子：
8
作者：
Lei G;Zhang Y;Hong T;Zhang X;Liu X;Mao C;Yan Y;Koppula P;Cheng W;Sood AK;Liu J;Gan B
通讯作者：
Gan B
影响因子：
39.3
作者：
Chen, Peng;Wu, Qibiao;Sui, Xinbing
通讯作者：
Sui, Xinbing
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M