Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy.
Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy.
复制标题
DOI：
10.1038/s41598-018-31916-2
复制
发表时间：
2018-09-11
影响因子：
4.6
通讯作者：
Andrié RP
中科院分区：
文献类型：
--
作者：
Luetkens JA;Wolpers AC;Beiert T;Kuetting D;Dabir D;Homsi R;Meendermann H;Dayé NA;Knappe V;Karsdal M;Nielsen SH;Genovese F;Stöckigt F;Linhart M;Thomas D;Nickenig G;Schild HH;Schrickel JW;Andrié RP
目的：探讨不同纤维化标志物和综合心脏磁共振(CMR)在预测房颤(AF)患者消融治疗不良反应中的应用价值。用CMR测量左房(LA)、晚期Gd增强(LGE)和自然LA-T1松弛时间。测定血浆松弛素、髓过氧化物酶和血清基质金属蛋白酶(MMPs)介导的心肌特异性肌动蛋白断裂和MMP介导IV型胶原降解的水平。不良预后以1年随访期间房颤复发为标准。61例患者进入最终分析。房颤复发20例(32.8%)。房颤复发组LA LGE百分率(26.7 ± 12.5%比17.0 ± 7.7%；P <； 0.001)、LA T1松弛时间(856.7 ± 112.2 ms比746.8 ± 91.0 ms；P <； 0.001)和血浆松弛素值(0.69 ± 1.34 pg/ml比0.37 ± 0.88 pg/ml)明显升高；P = 0.035)。在多因素COX回归分析中，晚期LGE分期(风险比(HR)：5.487；P = 为0.001)和T1松弛时间(HR：1.007；P = 0.001)对消融效果的预测效果最好。术前CMR是预测房颤患者导管消融治疗不良反应的有价值的工具。它提供了各种预测结果的成像技术，对于消融治疗前更好的患者选择可能是有价值的。
To determine the pre-procedural value of different fibrotic biomarkers and comprehensive cardiac magnetic resonance (CMR) for the prediction of poor response to ablation therapy in patients with atrial fibrillation (AF). Left atrial (LA) late gadolinium enhancement (LGE) and native LA T1 relaxation times were assessed using CMR. Plasma levels of relaxin, myeloperoxidase and serum levels of matrix metalloproteinase (MMP)-mediated cardiac specific titin fragmentation and MMP-mediated type IV collagen degradation were obtained. Poor outcome was defined by the recurrence of AF during 1-year follow-up. 61 patients were included in final analysis. Twenty (32.8%) patients had recurrence of AF. Patients with a recurrence of AF had a higher percentage of LA LGE (26.7 ± 12.5% vs. 17.0 ± 7.7%; P < 0.001), higher LA T1 relaxation times (856.7 ± 112.2 ms vs. 746.8 ± 91.0 ms; P < 0.001) and higher plasma levels of relaxin (0.69 ± 1.34 pg/ml vs. 0.37 ± 0.88 pg/ml; P = 0.035). In the multivariate Cox regression analysis, poor ablation outcome was best predicted by advanced LGE stage (hazard ratio (HR):5.487; P = 0.001) and T1 relaxation times (HR:1.007; P = 0.001). Pre-procedural CMR is a valuable tool for prediction of poor response to catheter ablation therapy in patients with AF. It offers various imaging techniques for outcome prediction and might be valuable for a better patient selection prior to ablation therapy.
登录
查看更多内容
急性心肌炎短期随访的综合心脏磁共振。
影响因子：
5.4
作者：
Luetkens JA;Homsi R;Dabir D;Kuetting DL;Marx C;Doerner J;Schlesinger-Irsch U;Andrié R;Sprinkart AM;Schmeel FC;Stehning C;Fimmers R;Gieseke J;Naehle CP;Schild HH;Thomas DK
通讯作者：
Thomas DK
影响因子：
6.1
作者：
Kirchhof, Paulus;Benussi, Stefano;Zeppenfeld, Katja
通讯作者：
Zeppenfeld, Katja
影响因子：
6.1
作者：
Letsas, Konstantinos P.;Weber, Reinhold;Arentz, Thomas
通讯作者：
Arentz, Thomas
T1 映射测量心肌纤维化的组织学验证：系统评价和荟萃分析
DOI：
10.1186/s12968-016-0313-7
发表时间：
2016-12-12
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Diao KY;Yang ZG;Xu HY;Liu X;Zhang Q;Shi K;Jiang L;Xie LJ;Wen LY;Guo YK
通讯作者：
Guo YK
影响因子：
37.8
作者：
Li, DS;Fareh, S;Nattel, S
通讯作者：
Nattel, S