Non-Viral Delivery of Gene Therapy to the Tendon.
Non-Viral Delivery of Gene Therapy to the Tendon.
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肌腱基因治疗的非病毒传递
作者：
肌腱作为一种致密的结缔组织，在急性撕裂或慢性退变后难以治疗。基于基因的疗法是一种针对多种疾病的高效策略，近年来在肌腱治疗中应用日益增多。随着技术的飞跃发展，已经制造出各种各样的非病毒载体，它们试图具备高生物安全性和转染效率，被认为是一种有前途的治疗方式。在这篇综述中，我们探讨了不利的生物屏障、适用基因的类别以及非病毒载体的介绍和比较。我们重点关注基于脂质的纳米颗粒和基于聚合物的纳米颗粒，并根据它们与不同化学修饰和支架的结合情况对它们进行区分。
The tendon, as a compact connective tissue, is difficult to treat after an acute laceration or chronic degeneration. Gene-based therapy is a highly efficient strategy for diverse diseases which has been increasingly applied in tendons in recent years. As technology improves by leaps and bounds, a wide variety of non-viral vectors have been manufactured that attempt to have high biosecurity and transfection efficiency, considered to be a promising treatment modality. In this review, we examine the unwanted biological barriers, the categories of applicable genes, and the introduction and comparison of non-viral vectors. We focus on lipid-based nanoparticles and polymer-based nanoparticles, differentiating between them based on their combination with diverse chemical modifications and scaffolds.
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
3.7
作者：
Lu P;Zhang GR;Song XH;Zou XH;Wang LL;Ouyang HW
通讯作者：
Ouyang HW
影响因子：
1.2
作者：
Aimaletdinov A;Mindubaeva G;Khalikova S;Kabwe E;Salmakova A;Alexandrova N;Rutland C;Rizvanov A;Zakirova E
通讯作者：
Zakirova E
影响因子：
17.1
作者：
Chan YK;Wang SK;Chu CJ;Copland DA;Letizia AJ;Costa Verdera H;Chiang JJ;Sethi M;Wang MK;Neidermyer WJ Jr;Chan Y;Lim ET;Graveline AR;Sanchez M;Boyd RF;Vihtelic TS;Inciong RGCO;Slain JM;Alphonse PJ;Xue Y;Robinson-McCarthy LR;Tam JM;Jabbar MH;Sahu B;Adeniran JF;Muhuri M;Tai PWL;Xie J;Krause TB;Vernet A;Pezone M;Xiao R;Liu T;Wang W;Kaplan HJ;Gao G;Dick AD;Mingozzi F;McCall MA;Cepko CL;Church GM
通讯作者：
Church GM
影响因子：
17.1
作者：
Anselmo, Aaron C.;Zhang, Mengwen;Mitragotri, Samir
通讯作者：
Mitragotri, Samir