Effectiveness and safety of repeat dexamethasone for bronchopulmonary dysplasia.
Effectiveness and safety of repeat dexamethasone for bronchopulmonary dysplasia.
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DOI：
10.1038/s41372-021-01125-3
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Truog WE
中科院分区：
文献类型：
--
作者：
Cuna A;Quiqley A;Varghese K;Ciccolari-Micaldi G;Oliveros C;Cheng AL;Norberg M;Truog WE
描述重复地塞米松治疗支气管肺发育不良（BPD）的有效性，并评价其对生长的不良影响。1或2疗程地塞米松治疗BPD婴儿的回顾性研究。有效性定义为治疗结束时呼吸支持的成功降压。分析了对生长的不良影响，并与未处理的对照组进行了比较。共发现132例地塞米松治疗的婴儿。总的来说，52%（69/132）的初始地塞米松治疗的婴儿呼吸支持下降，而38%（20/52）的重复地塞米松治疗的婴儿呼吸支持下降。与对照组相比，接受1或2个疗程地塞米松治疗的婴儿的生长轨迹无显著差异（体重：P = 0.23，体长：P = 0.68，头围：P = 0.77）。与初始疗程相比，重复地塞米松治疗BPD的断奶呼吸支持效果较差。在对照组和接受1或2个疗程地塞米松治疗的婴儿之间，生长参数到出院的变化具有可比性。
To describe effectiveness of repeat dexamethasone for bronchopulmonary dysplasia (BPD) and to evaluate adverse effects on growth. Retrospective study of infants treated with 1 or 2 courses of dexamethasone for BPD. Effectiveness was defined as successful step-down in respiratory support by end of treatment. Adverse effects on growth were analyzed and compared to untreated controls. A total of 132 dexamethasone-treated infants were identified. In total, 52% (69/132) of infants treated with initial dexamethasone achieved step-down in respiratory support compared to 38% (20/52) of infants with repeat dexamethasone. Growth trajectory did not significantly differ among infants treated with 1 or 2 courses of dexamethasone compared with controls (weight: P = 0.23, length: P = 0.68, and head circumference: P = 0.77). Repeat dexamethasone for BPD was less effective in weaning respiratory support compared to initial course. Changes in growth parameters to discharge were comparable between controls and infants treated with 1 or 2 dexamethasone courses.
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影响因子：
8
作者：
Doyle, LW;Davis, PG;Carlin, JB
通讯作者：
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DOI：
10.1080/14767058.2020.1752653
发表时间：
2020-04-14
影响因子：
1.8
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作者：
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影响因子：
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作者：
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通讯作者：
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