The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis.
The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis.
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DOI：
10.3390/ijms19010092
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发表时间：
2017-12-29
影响因子：
5.6
通讯作者：
Nakase H
中科院分区：
文献类型：
--
作者：
Hirayama D;Iida T;Nakase H
巨噬细胞是先天免疫系统的效应细胞，其吞噬细菌并分泌促炎介质和抗微生物介质。此外，巨噬细胞通过其程序性细胞死亡在消除患病和受损细胞中发挥重要作用。通常，巨噬细胞摄取并降解死细胞、碎片、肿瘤细胞和异物。它们通过响应体内和外部的变化来促进体内平衡，不仅作为吞噬细胞，而且还通过营养，调节和修复功能。最近的研究表明，巨噬细胞分化造血干细胞来源的单核细胞和胚胎卵黄囊巨噬细胞。后者主要产生组织巨噬细胞。大分子化合物存在于所有脊椎动物组织中，具有保护宿主和损伤组织的双重功能，并维持在一种良好的平衡状态。组织巨噬细胞在不同的组织环境中具有异质性表型。在这篇综述中，我们集中在巨噬细胞的吞噬功能，加强先天免疫和组织内稳态更好地了解组织巨噬细胞在几种病理条件下的作用。
Macrophages are effector cells of the innate immune system that phagocytose bacteria and secrete both pro-inflammatory and antimicrobial mediators. In addition, macrophages play an important role in eliminating diseased and damaged cells through their programmed cell death. Generally, macrophages ingest and degrade dead cells, debris, tumor cells, and foreign materials. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes, but also through trophic, regulatory, and repair functions. Recent studies demonstrated that macrophages differentiate from hematopoietic stem cell-derived monocytes and embryonic yolk sac macrophages. The latter mainly give rise to tissue macrophages. Macrophages exist in all vertebrate tissues and have dual functions in host protection and tissue injury, which are maintained at a fine balance. Tissue macrophages have heterogeneous phenotypes in different tissue environments. In this review, we focused on the phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis for a better understanding of the role of tissue macrophages in several pathological conditions.
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